Cumulative adverse events to week 24 (safety population)
| Cumulative results for: | Tocilizumab 8 mg/kg(n = 288) | Methotrexate(n = 284) | p Value |
| Any adverse event | 230 (79.9) | 220 (77.5) | 0.484 |
| Serious adverse event | 11 (3.8) | 8 (2.8) | 0.504 |
| Related serious adverse event | 4 (1.4) | 4 (1.4) | 0.984 |
| Adverse event leading to discontinuation | 11 (3.8) | 15 (5.3) | 0.401 |
| Adverse event leading to dose modification | 56 (19.4) | 63 (22.2) | 0.420 |
| Death | 3 (1.0) | 1 (0.4) | 0.322 |
Results are shown an n (%).