Table 1 Overview of current European biologicals registers

Name	Started in/by	Coordination	Type of register/study	Inclusion criteria/sample size	Controls	Current size	Follow-up	Remarks	Website
British Society for Rheumatology Biologics Register (BSRBR)2 6 12 18 21^–24	October 2001 by British Society for Rheumatology	ARC Epidemiology Unit Manchester	Epidemiological cohort study	New prescription of biologicals; 4000 per drug	Control group collected at defined sites	Biologicals: >14 000 controls: >3000	Baseline, 3, 6, 12, 18, 24, 30, 36, 48, 60 months	Inclusion mandatory according to NICE	http://www.medicine.manchester.ac.uk/arc/BSRBR
German Biologics Register (RABBIT)5 25^–27	May 2001 by German Society for Rheumatology	Epidemiology Unit, German Rheumatism Research Centre	Epidemiological cohort study	New prescription of biologicals; 1000 per drug	Internal control group: DMARD failures	Biologicals: >3500 controls: 1800	Baseline, 3, 6, 12, 18, 24, 30, 36, 48, 60, 72, 84, 96, 108, 120 months		http://www.biologika-register.de
Swedish Biologics Register (ARTIS)7 28^–31	Swedish Rheumatology Association	Karolinska Institute, Stockholm	Routine registration	New prescription of biologicals	National register data	15 000 treatments	Baseline, 3, 6, 12, 18, 24 months etc	Two regional registers in South Sweden and the Stockholm area contribute to ARTIS	http://www.rareg.net/cms/sv/home
Spanish BIOBADASER register8 10 32^–35	2000 by Spanish Society for Rheumatology	Research Unit of Spanish Society of Rheumatology	Routine registration	New prescription of biologicals	EMECAR cohort	>8000 patients	Registration at inception of adverse event	Since 2006 reduction to 14 participating hospitals	http://biobadaser.ser.es
Danish Rheumatologic database (DANBIO)36^–40	2000 by Danish Society of Rheumatology and Institute for Rational Pharmacotherapy	Hvidovre Hospital	Routine registration in 26 rheumatological departments	New prescriptions		>3500 patients with RA	No defined follow-up but follow-up at regular visits as long as patient is seen in department		https://danbio-online.dk
Norwegian DMARD register (NOR-DMARD)41^–44	2000 by five rheumatology centres	Diakonhjemmet Hospital, Oslo	Routine registration of all DMARDs and biologicals	Treatment start with DMARD or biological agent	DMARDs	>2000 RA/AS/PsA (biologicals) >3000 DMARDs	Baseline, 3, 6, 12, 24, 36, etc, months	Not specifically set up as biologicals register
Dutch Rheumatoid Arthritis Monitoring Register (DREAM)45	2003 by 11 rheumatology centres	Radboud University Nijmegen Medical Centre	Epidemiological cohort study	Start of treatment with biological agent	Early RA cohort	>1000 patients	Baseline, 3, 6, 9, 12, 18, 24, 30, 36 etc, months
Swiss Clinical Quality Management Database46^–48	1996 as quality management system	University of Geneva	Routine registration	Start of treatment with biological agent	DMARD patients	>2000 patients	Annually	Not specifically set up as biologicals register	http://www.scqm.ch

ARC, Arthritis Research Campaign; AS, ankylosing spondylitis; DMARD, disease-modifying antirheumatic drug; EMECAR, Estudio de la Morbilidad y Expresión Clínica de la Artritis Reumatoide; NICE, National Institute of Clinical Excellence; PsA, psoriatic arthritis; RA, rheumatoid arthritis.