Table 1 Overview of current European biologicals registers
NameStarted in/byCoordinationType of register/studyInclusion criteria/sample sizeControlsCurrent sizeFollow-upRemarksWebsite
British Society for Rheumatology Biologics Register (BSRBR)2 6 12 18 2124October 2001 by British Society for RheumatologyARC Epidemiology Unit ManchesterEpidemiological cohort studyNew prescription of biologicals; 4000 per drugControl group collected at defined sitesBiologicals: >14 000 controls: >3000Baseline, 3, 6, 12, 18, 24, 30, 36, 48, 60 monthsInclusion mandatory according to NICE
German Biologics Register (RABBIT)5 2527May 2001 by German Society for RheumatologyEpidemiology Unit, German Rheumatism Research CentreEpidemiological cohort studyNew prescription of biologicals; 1000 per drugInternal control group: DMARD failuresBiologicals: >3500 controls: 1800Baseline, 3, 6, 12, 18, 24, 30, 36, 48, 60, 72, 84, 96, 108, 120 months
Swedish Biologics Register (ARTIS)7 2831Swedish Rheumatology AssociationKarolinska Institute, StockholmRoutine registrationNew prescription of biologicalsNational register data15 000 treatmentsBaseline, 3, 6, 12, 18, 24 months etcTwo regional registers in South Sweden and the Stockholm area contribute to ARTIS
Spanish BIOBADASER register8 10 32352000 by Spanish Society for RheumatologyResearch Unit of Spanish Society of RheumatologyRoutine registrationNew prescription of biologicalsEMECAR cohort>8000 patientsRegistration at inception of adverse eventSince 2006 reduction to 14 participating hospitals
Danish Rheumatologic database (DANBIO)36402000 by Danish Society of Rheumatology and Institute for Rational PharmacotherapyHvidovre HospitalRoutine registration in 26 rheumatological departmentsNew prescriptions>3500 patients with RANo defined follow-up but follow-up at regular visits as long as patient is seen in department
Norwegian DMARD register (NOR-DMARD)41442000 by five rheumatology centresDiakonhjemmet Hospital, OsloRoutine registration of all DMARDs and biologicalsTreatment start with DMARD or biological agentDMARDs>2000 RA/AS/PsA (biologicals) >3000 DMARDsBaseline, 3, 6, 12, 24, 36, etc, monthsNot specifically set up as biologicals register
Dutch Rheumatoid Arthritis Monitoring Register (DREAM)452003 by 11 rheumatology centresRadboud University Nijmegen Medical CentreEpidemiological cohort studyStart of treatment with biological agentEarly RA cohort>1000 patientsBaseline, 3, 6, 9, 12, 18, 24, 30, 36 etc, months
Swiss Clinical Quality Management Database46481996 as quality management systemUniversity of GenevaRoutine registrationStart of treatment with biological agentDMARD patients>2000 patientsAnnuallyNot specifically set up as biologicals register
  • ARC, Arthritis Research Campaign; AS, ankylosing spondylitis; DMARD, disease-modifying antirheumatic drug; EMECAR, Estudio de la Morbilidad y Expresión Clínica de la Artritis Reumatoide; NICE, National Institute of Clinical Excellence; PsA, psoriatic arthritis; RA, rheumatoid arthritis.