Table 1

Characteristics of patients presenting with systemic sclerosis and depressed versus normal left ventricular ejection fraction (LVEF)

LVEFp Value
Depressed(n = 383)Normal(n = 6690)
Mean (SD) age (years)61.3 (13.4)56.1 (13.7)<0.001
M/F (%)23/7713/87<0.001
Disease duration (years)12.0 (9.7)9.6 (7.8)<0.001
Cutaneous subtype
    Diffuse (%)47.532.0<0.001
Friction rub (%)19.210.8<0.001
Synovitis (%)23.316.2<0.001
Raynaud’s syndrome (%)96.995.40.181
Digital ulceration (%)52.430.5<0.001
Muscle weakness (%)47.925.9<0.001
Pulmonary fibrosis (plain radiography) (%)56.935.5<0.001
Elevated systolic PAP (%)50.718.7<0.001
Palpitations (%)48.923.1<0.001
Conduction abnormality on ECG (%)33.39.1<0.001
Renal crisis (%)8.21.9<0.001
Positive antinuclear antibodies (%)92.491.90.736
Positive antitopoisomerase-1 antibodies (%)37.532.10.030
Positive anticentromere antibodies (%)25.734.50.001
Elevated creatine phosphokinase (%)11.48.00.019
Elevation of acute phase reactants (%)50.029.4<0.001
Proteinuria (%)15.35.45<0.001
Active disease according to European score (%)51.129.1<0.001
  • PAP, pulmonary artery pressure.