Characteristics of patients presenting with systemic sclerosis and depressed versus normal left ventricular ejection fraction (LVEF)
| LVEF | p Value | ||
| Depressed(n = 383) | Normal(n = 6690) | ||
| Mean (SD) age (years) | 61.3 (13.4) | 56.1 (13.7) | <0.001 |
| M/F (%) | 23/77 | 13/87 | <0.001 |
| Disease duration (years) | 12.0 (9.7) | 9.6 (7.8) | <0.001 |
| Cutaneous subtype | |||
| Diffuse (%) | 47.5 | 32.0 | <0.001 |
| Friction rub (%) | 19.2 | 10.8 | <0.001 |
| Synovitis (%) | 23.3 | 16.2 | <0.001 |
| Raynaud’s syndrome (%) | 96.9 | 95.4 | 0.181 |
| Digital ulceration (%) | 52.4 | 30.5 | <0.001 |
| Muscle weakness (%) | 47.9 | 25.9 | <0.001 |
| Pulmonary fibrosis (plain radiography) (%) | 56.9 | 35.5 | <0.001 |
| Elevated systolic PAP (%) | 50.7 | 18.7 | <0.001 |
| Palpitations (%) | 48.9 | 23.1 | <0.001 |
| Conduction abnormality on ECG (%) | 33.3 | 9.1 | <0.001 |
| Renal crisis (%) | 8.2 | 1.9 | <0.001 |
| Positive antinuclear antibodies (%) | 92.4 | 91.9 | 0.736 |
| Positive antitopoisomerase-1 antibodies (%) | 37.5 | 32.1 | 0.030 |
| Positive anticentromere antibodies (%) | 25.7 | 34.5 | 0.001 |
| Elevated creatine phosphokinase (%) | 11.4 | 8.0 | 0.019 |
| Elevation of acute phase reactants (%) | 50.0 | 29.4 | <0.001 |
| Proteinuria (%) | 15.3 | 5.45 | <0.001 |
| Active disease according to European score (%) | 51.1 | 29.1 | <0.001 |
PAP, pulmonary artery pressure.