Table 1 Excluded studies and reason for exclusion
StudyReason for exclusion
Calguneri, 1999No methotrexate monotherapy arm (data combined with sulfazalazine and hydroxychloroquine monotherapy)
Clegg, 1997No outcome of interest
Haagsma, 1995Summary of Haagsma et al. (included in this review)27
Kremer, 2004Open-label extension of randomised controlled trial
Maillefert, 2003Open-label extension of randomised controlled trial
Matucci-Cerinic, 2003Summary of Kremer et al. (included in this review)20
Mottaghi, 2005Non-randomised controlled trial
Mroczkowski, 1999Open-label extension of randomised controlled trial
Nagashima, 2006Non-randomised controlled trial
Nisar, 1994Non-randomised controlled trial
O’Dell, 1996Open-label extension of randomised controlled trial
Rau, 1998Non-randomised controlled trial
Stein, 1997Open-label extension of randomised controlled trial
Trnavsky, 1993No methotrexate monotherapy arm
Willkens, 1996Published in the journal supplements and the key data have been reported in Willkens et al (included in this review)25
Krause D et al (German), 1998Non-randomised controlled trial
Geokoop-Ruiterman YPM, 2005No MTX monotherapy arm
Geokoop-Ruiterman YPM, 2007No MTX monotherapy arm
Mottonen T et al, 1999No MTX monotherapy arm