| Retrieved references by systematic literature search (n) | Articles included in the systematic reviews (n) | |
| Pre-methotrexate work-up | 1214 | 52 |
| Dosage and route | 1748 | 50 |
| Folic acid | 334 | 9 |
| Monitoring | 857 | 23 |
| Hepatotoxicity | 426 | 46 |
| Long-term safety | 2449 | 88 |
| Mono vs combination | 6958 | 20 |
| Steroid-sparing agent | 527 | 6 |
| Perioperative period | 303 | 4 |
| Pregnancy | 2163 | 6 |
| Total | 16 979 | 304 |