Table 2 Comparison of frequencies of laboratory findings in patients with IgG4-positive multiorgan lymphoproliferative syndrome (IgG4+MOLPS) and those with typical Sjögren’s syndrome (SS)
IgG4+MOLPSTypical SSNormal rangep Value†p Value‡p Value§
All(n = 64)Women(n = 33)Men(n = 31)All(n = 31)Women(n = 29)
RF26.6% (17)33.3% (11)19.4% (6)87.1% (27)86.2% (25)<0.001<0.0010.263
ANA23.4% (15)15.2% (5)32.3% (10)90.3% (28)89.7% (26)<0.001<0.0010.143
A-SSA1.6% (1)0.0% (0)3.2% (1)100.0% (31)100.0% (29)<0.001<0.0010.484
A-SSB0.0% (0)0.0% (0)0.0% (0)100.0% (31)100.0% (29)<0.001<0.001NE
Low CH5057.8% (37)57.6% (19)58.1% (18)48.4% (15)51.7% (15)0.5100.7991.000
IgG (mg/dl)2960.1 (1.7)2661.3 (1.7)3315.9 (1.7)2473.4 (1.4)2459.2 (1.4)870–17000.0420.4580.104
IgG1 (mg/dl)1155.3 (1.6)1025.2 (1.5)1338.4 (1.7)1437.1 (1.5)1417.1 (1.5)320–7480.0390.0040.038
IgG2 (mg/dl)786.5 (1.5)737.2 (1.6)851.7 (1.5)566.6 (1.6)545.8 (1.5)208–7540.0010.0090.206
IgG3 (mg/dl)57.6 (2.8)48.2 (2.8)71.9 (2.8)81.9 (1.8)83.5 (1.8)6.6–88.30.0470.0130.147
IgG4 (mg/dl)697.7 (2.6)690.9 (2.6)705.5 (2.7)23.5 (2.1)21.3 (1.9)4.8–105<0.001<0.0010.933
IgA (mg/dl)194.7 (1.80)178.3 (2.0)213.8 (1.5)389.7 (1.7)377.1 (1.7)110–410<0.001<0.0010.199
IgM (mg/dl)63.0 (2.0)69.6 (2.0)56.6 (2.1)147.3 (1.7)145.7 (1.7)35–220<0.001<0.0010.249
IgE (IU/ml)307.4 (4.0)182.6 (4.3)566.5 (2.8)15.3 (1.4)15.2 (1.3)<1730.0050.0300.033
  • Values are shown as geometrical means (geometrical SD) for IgG, IgG1, IgG2, IgG3, IgG4, IgE, IgA and IgM.

  • Incidence rates (numbers of positive patients) are shown for RF, ANA, A-SSA, A-SSB and low CH50.

  • IgE was examined in 50 patients (not all) with IgG4+MOLPS. IgG1, IgG2 and IgG3 were examined in 58 patients (not all) with IgG4+MOLPS.

  • †All IgG4+MOLPS vs typical SS.

  • ‡Female IgG4+MOLPS vs typical SS.

  • §Female vs male IgG4+MOLPS.

  • ANA, antinuclear antibody; A-SSA, anti-SS-A/Ro antibody; A-SSB, anti-SS-B/La antibody; CH50, 50% haemolytic unit of complement; NE, not examined; RF, rheumatoid factor.