Ref | Patients n (n with RA) | RA disease duration* | Control patients diagnosis† | Sensitivity (%) (95% CI) | Specificity (%)(95% CI) |
Early RA, list format | |||||
7 | 270 (98) | <1 year | 1.7/98.3 | 66 (56 to 76) | 82 (75 to 87) |
11 | 217 (39) | <1 year | 0/100 | 90 (76 to 97) | 90 (84 to 94) |
12 | 279 (138) | 5 months (84% <1 year) | 0/100 | 62 (54 to 70) | 50 (42 to 59) |
16 | 221 (121) | <6 months | 0/100 | 83 (76 to 90) | 86 (78 to 92) |
23 | 135 (135) | 3.5 months | 74 (66 to 81) | – | |
24 | 23 (15) | <3 months | 0/100 | 93 (68 to 100) | 63 (24 to 91) |
Pooled | 77 (68 to 84) | 77 (68 to 84) | |||
Early RA, tree format | |||||
12 | 279 (138) | 5 months (84% <1 year) | 0/100 | 78 (70 to 85) | 35 (27 to 43) |
24 | 23 (15) | <3 months | 0/100 | 93 (63 to 100) | 13 (0 to 53) |
Pooled | 80 (72 to 88) | 33 (24 to 43) | |||
Established RA, list format | |||||
6 | 524 (262) | 7.7 years | 31.7/68.3 | 91 (87 to 94) | 89 (85 to 93) |
7 | 270 (80) | >2 years | 1.7/98.3 | 91 (83 to 96) | 75 (68 to 81) |
10 | 217 (128) | NA | 0/100 | 63 (54 to 72) | – |
13 | 298 (113) | 12.1 years | 22.2/77.8 | 95 (89 to 98) | 73 (66 to 79) |
14 | 52 (52) | 4.5 years | 77 (63 to 87) | – | |
15 | 292 (146) | NA | 30.8/69.2 | 73 (65 to 80) | 87 (80 to 92) |
17 | 283 (255) | NA | 0/100 | 56 (50 to 63) | 86 (67 to 96) |
18 | 173 (82) | NA | 0/100 | 37 (26 to 48) | 99 (94 to 100) |
19 | 182 (151) | 16 years | 0/100 | 71 (63 to 78) | 94 (79 to 99) |
20 | 1338 (1338) | 5.4 years (32% <1 year) | 66 (63 to 69) | – | |
20 | 1450 (93) | 35%<1year | 70/30 | 82 (72 to 89) | 98 (97 to 99) |
21 | 165 (111) | 6.6 years | 7.4/92.6 | 91 (84 to 96) | 89 (77 to 96) |
22 | 212 (90) | 3 years | 41/59 | 87 (78 to 93) | 85 (78 to 91) |
25 | 817 (362) | 7.9 years | 7.5/92.5 | 90 (86 to 93) | 95 (93 to 97) |
26 | 290 (154) | NA | 11.8/88.2 | 88 (82 to 93) | 93 (88 to 97) |
Pooled | 79 (71 to 85) | 90 (84 to 94) | |||
Established RA, tree format | |||||
6 | 524 (262) | 7.7 years | 31.7/68.3 | 94 (90 to 96) | 89 (84 to 92) |
10 | 217 (128) | NA | 0/100 | 65 (56 to 73) | – |
14 | 52 (52) | 4.5 years | 96 (87 to 100) | – | |
17 | 283 (255) | NA | 0/100 | 58 (52 to 64) | 83 (63 to 94) |
20 | 1450 (93) | 35% <1 year | 70/30 | 89 (81 to 95) | 98 (97 to 99) |
20 | 1338 (1338) | 5.4 years (32% <1 year) | 71 (68 to 73) | – | |
Pooled | 80 (71 to 85) | 93 (86 to 97) |
*RA disease duration is expressed as mean, median, or limit for inclusion; †diagnosis: mechanical (%)/inflammatory diseases (%).