Table 3 Effect of etanercept therapy on the occurrence of malignancies in randomised controlled trials
DatasetModelEvents in etanercept groupEvents in control groupHR (95% CI)p Value
FullFixed effects survival model stratified by trial2671.84 (0.79 to 4.28)0.16
FullRandom effects survival model stratified by trial2671.82 (0.78 to 4.22)0.17
NMSC excludedFixed effects survival model stratified by trial1741.86 (0.62 to 5.59)0.27
Cancers diagnosed within first 42 days excludedFixed effects survival model stratified by trial2361.87 (0.75 to 4.62)0.18
<6 MonthsFixed effects survival model stratified by trial831.52 (0.35 to 6.55)0.99
6–12 MonthsFixed effects survival model stratified by trial1215.81 (0.73 to 46.16)0.17
>12 MonthsFixed effects survival model stratified by trial630.88 (0.21 to 3.66)0.86
FullFixed effects survival model, treatment varying with ln(time)2670.97 (0.47 to 2.01)0.93
Aggregate dataFixed effects Mantel–Haenszel model2671.93 (0.85 to 4.38)0.12
Aggregate dataRandom effects DerSimonian and Laird model2671.71 (0.73 to 4.01)0.21
  • HR, hazard ratio; NMSC, non-melanoma skin cancer.