Table 2 Summary of malignancies in the randomised controlled trials
Trial referenceEtanercept-treated participants (N  =  2244)Control patients (N  =  1072)
Patients with ⩾1 malignancy/type of malignancyEtanercept doseTime point of diagnosisPatients with ⩾1 malignancy/type of malignancyTime point of diagnosis
TNR 001020––0–
Unpublished
1600040––0–
Moreland et al, 199720
1600091 Lung adenocarcinoma25 mg biwWeek 400
Moreland et al, 199921
160012Bathon et al, 2000161 Ductal breast cancer10 mg biwWeek 451 Non-melanoma skin cancerWeek 12
1 Prostate adenocarcinoma25 mg biwWeek 391 Urethral carcinomaWeek 56
Genovese et al, 2002181 Basal cell carcinoma10 mg biwWeek 911 Colon adenocarcinomaWeek 40
1 Lobular breast carcinoma10 mg biwWeek 1021 Basal cell carcinomaWeek 86
1 Basal cell carcinoma25 mg biwWeek 47
1 Basal cell carcinoma25 mg biwWeek 44
1 Lung carcinoid25 mg biwWeek 37
1 Basal cell carcinoma20 mg biwWeek 40
1 Lung NSCC10 mg biwWeek 9
1 Hodgkin lymphoma25 mg biwWeek 37
1600140––0–
Weinblatt et al, 199923
160029Baumgartner et al, 200424 (abstract)1 Squamous cell carcinoma skin25 mg biwWeek 21 Basal cell carcinomaWeek 3
1 Basal cell carcinoma25 mg biwWeek 91 Lung squamous cell carcinomaWeek 11
08813000
Ericson and Wadjula, 199926 (abstract)1 LGL syndrome (monoclonal)10 mg biwWeek 1
1 Ductal breast carcinoma10 mg qwWeek 4
0881308Klareskog et al, 2004191 Ductal breast carcinoma25 mg biwWeek 341 Ductal breast carcinomaWeek 64
1 Adenocarcinoma of the rectum25 mg biwWeek 24
van der Heijde et al, 2006221 Oesophageal adenocarcinoma25 mg biwWeek 58
van der Heijde et al, 200628 (abstract)1 Basal cell carcinoma25 mg biwWeek 36
1 Colon carcinoma25 mg biwWeek 84
Mola et al, 200627 (abstract)1 Lung adenocarcinoma25 mg biwWeek 64
1 Malignant melanoma25 mg biwWeek 9
1 Basal cell carcinoma25 mg biwWeek 45
1 Basal cell carcinoma25 mg biwWeek 30
1 Endometrium carcinoma25 mg biwWeek 106
0881309Combe et al, 2006171 Acute myelogenous leukemia25 mg biwWeek 120–
Combe et al, 200525 (abstract)

  • biw, twice weekly; LGL, large granular lymphocyte; NSCC, non-small-cell carcinoma; qw, every week.