Table 4

Results for 24-month follow-up using MRI and comparison with radiography: mean annualised change (MC) in cartilage thickness (ThCtAB) in mm (percentage of the baseline values given in brackets) and SRMs between baseline and follow-up measurements for participants with different KLGs

Healthy reference (KLG0), MC (%)SRMOA participants (KLG2), MC (%)SRMKLG3, MC (%)SRM
LS mJSW−0.02 (−0.5)−0.17−0.07 (−1.9)−0.32−0.22 (−5.6)††−0.62**
FF mJSW0.0 (−0.1)−0.020.03 (0.7)0.11−0.07 (−1.7)−0.20
MFTC−0.01 (−0.3)−0.25*0.0 (0.0)0.03−0.05 (−1.6)−0.44*
cMFTC−0.02 (−0.5)−0.32**−0.01 (−0.3)−0.15−0.09 (−2.2)−0.48*
MT−0.01 (−0.4)−0.31**−0.01 (−0.4)−0.25−0.02 (−1.4)†−0.59**
cMT−0.01 (−0.6)−0.33**−0.02 (−0.8)−0.3−0.04 (−2.0)−0.53**
eMT−0.01 (−0.4)−0.19−0.01 (−0.9)−0.29−0.05 (−3.4)††−0.57**
iMT0.0 (0.0)0.01−0.01 (−0.5)−0.21−0.01 (−0.6)−0.29
aMT−0.01 (−0.6)−0.35**0.0 (−0.2)−0.09−0.02 (−1.2)−0.32
pMT0.0 (−0.1)−0.080.0 (0.0)0.010.0 (0.0)−0.02
cMF0.0 (−0.3)−0.130.01 (0.5)†0.30−0.03 (−1.9)−0.34
ccMF−0.01 (−0.4)−0.160 (0.2)0.07−0.05 (−2.4)−0.35
ecMF0 (0.2)0.090.02 (1.3)†0.50*−0.04 (−3.0)−0.34
icMF−0.01 (−0.4)−0.170.0 (0.2)0.09−0.01 (−0.5)−0.18
LFTC0.0 (−0.1)−0.09−0.02 (−0.4)−0.230.0 (0.1)0.06
cLFTC0.0 (−0.1)−0.06−0.04 (−0.9)−0.3−0.02 (−0.3)−0.15
LT−0.01 (−0.4)−0.30**−0.02 (−1.1)−0.57**−0.01 (−0.5)−0.35
cLT−0.01 (−0.3)−0.16−0.05 (−1.7)−0.47*−0.02 (−0.8)−0.29
eLT0.0 (−0.2)−0.110.0 (0.0)0.01−0.01 (−0.4)−0.19
iLT0.0 (−0.2)−0.1−0.03 (−1.4)†−0.53*−0.01 (−0.3)−0.16
aLT−0.01 (−0.5)−0.19−0.01 (−0.7)−0.320.0 (0.2)0.08
pLT−0.02 (−1.0)−0.36**−0.02 (−1.1)−0.51*−0.02 (−1.0)−0.31
cLF0.0 (0.3)0.160.01 (0.3)0.130.01 (0.8)0.32
ccLF0.01 (0.3)0.140 (0.2)0.080.01 (0.4)0.16
ecLF0.0 (0.3)0.110.01 (0.6)0.210.03 (1.9)†0.56**
icLF0.0 (0.3)0.140.0 (0.2)0.070.0 (0.1)0.05
  • *p<0.05, **p<0.01, ***p<0.001 for change between baseline and follow-up examination; †p<0.05, ††p<0.01, †††p<0.001 for differences in changes between KLG2 vs KLG0 and KLG3 vs KLG0, respectively.

  • a, anterior; c, central; cLF, central weight-bearing lateral femoral condyle; cLFTC, central LFTC (cLT+ccLF); cMF, central weight-bearing medial femoral condyle; cMFTC, central MFTC (cMT+ccMF); e, external; FF, fixed flexion radiography; i, internal; KLG, Kellgren–Lawrence grade; LFTC, lateral femorotibial compartment; LS, Lyon–Schuss radiography; LT, lateral tibia; MFTC, medial femorotibial compartment; mJSW, minimum joint space width; MT, medial tibia; OA, osteoarthritis; p, posterior; SRM, standardised response mean (mean change/standard deviation of the change); ThCtAB, total area of subchondral bone.