Healthy reference (KLG0), MC (%) | SRM | OA participants (KLG2), MC (%) | SRM | KLG3, MC (%) | SRM | |
LS mJSW | −0.02 (−0.5) | −0.17 | −0.07 (−1.9) | −0.32 | −0.22 (−5.6)†† | −0.62** |
FF mJSW | 0.0 (−0.1) | −0.02 | 0.03 (0.7) | 0.11 | −0.07 (−1.7) | −0.20 |
MFTC | −0.01 (−0.3) | −0.25* | 0.0 (0.0) | 0.03 | −0.05 (−1.6) | −0.44* |
cMFTC | −0.02 (−0.5) | −0.32** | −0.01 (−0.3) | −0.15 | −0.09 (−2.2) | −0.48* |
MT | −0.01 (−0.4) | −0.31** | −0.01 (−0.4) | −0.25 | −0.02 (−1.4)† | −0.59** |
cMT | −0.01 (−0.6) | −0.33** | −0.02 (−0.8) | −0.3 | −0.04 (−2.0) | −0.53** |
eMT | −0.01 (−0.4) | −0.19 | −0.01 (−0.9) | −0.29 | −0.05 (−3.4)†† | −0.57** |
iMT | 0.0 (0.0) | 0.01 | −0.01 (−0.5) | −0.21 | −0.01 (−0.6) | −0.29 |
aMT | −0.01 (−0.6) | −0.35** | 0.0 (−0.2) | −0.09 | −0.02 (−1.2) | −0.32 |
pMT | 0.0 (−0.1) | −0.08 | 0.0 (0.0) | 0.01 | 0.0 (0.0) | −0.02 |
cMF | 0.0 (−0.3) | −0.13 | 0.01 (0.5)† | 0.30 | −0.03 (−1.9) | −0.34 |
ccMF | −0.01 (−0.4) | −0.16 | 0 (0.2) | 0.07 | −0.05 (−2.4) | −0.35 |
ecMF | 0 (0.2) | 0.09 | 0.02 (1.3)† | 0.50* | −0.04 (−3.0) | −0.34 |
icMF | −0.01 (−0.4) | −0.17 | 0.0 (0.2) | 0.09 | −0.01 (−0.5) | −0.18 |
LFTC | 0.0 (−0.1) | −0.09 | −0.02 (−0.4) | −0.23 | 0.0 (0.1) | 0.06 |
cLFTC | 0.0 (−0.1) | −0.06 | −0.04 (−0.9) | −0.3 | −0.02 (−0.3) | −0.15 |
LT | −0.01 (−0.4) | −0.30** | −0.02 (−1.1) | −0.57** | −0.01 (−0.5) | −0.35 |
cLT | −0.01 (−0.3) | −0.16 | −0.05 (−1.7) | −0.47* | −0.02 (−0.8) | −0.29 |
eLT | 0.0 (−0.2) | −0.11 | 0.0 (0.0) | 0.01 | −0.01 (−0.4) | −0.19 |
iLT | 0.0 (−0.2) | −0.1 | −0.03 (−1.4)† | −0.53* | −0.01 (−0.3) | −0.16 |
aLT | −0.01 (−0.5) | −0.19 | −0.01 (−0.7) | −0.32 | 0.0 (0.2) | 0.08 |
pLT | −0.02 (−1.0) | −0.36** | −0.02 (−1.1) | −0.51* | −0.02 (−1.0) | −0.31 |
cLF | 0.0 (0.3) | 0.16 | 0.01 (0.3) | 0.13 | 0.01 (0.8) | 0.32 |
ccLF | 0.01 (0.3) | 0.14 | 0 (0.2) | 0.08 | 0.01 (0.4) | 0.16 |
ecLF | 0.0 (0.3) | 0.11 | 0.01 (0.6) | 0.21 | 0.03 (1.9)† | 0.56** |
icLF | 0.0 (0.3) | 0.14 | 0.0 (0.2) | 0.07 | 0.0 (0.1) | 0.05 |
*p<0.05, **p<0.01, ***p<0.001 for change between baseline and follow-up examination; †p<0.05, ††p<0.01, †††p<0.001 for differences in changes between KLG2 vs KLG0 and KLG3 vs KLG0, respectively.
a, anterior; c, central; cLF, central weight-bearing lateral femoral condyle; cLFTC, central LFTC (cLT+ccLF); cMF, central weight-bearing medial femoral condyle; cMFTC, central MFTC (cMT+ccMF); e, external; FF, fixed flexion radiography; i, internal; KLG, Kellgren–Lawrence grade; LFTC, lateral femorotibial compartment; LS, Lyon–Schuss radiography; LT, lateral tibia; MFTC, medial femorotibial compartment; mJSW, minimum joint space width; MT, medial tibia; OA, osteoarthritis; p, posterior; SRM, standardised response mean (mean change/standard deviation of the change); ThCtAB, total area of subchondral bone.