Table 3

Results for 12-month follow-up using MRI and comparison with radiography: mean annualised change (MC) in cartilage thickness (ThCtAB) in mm (percentage of the baseline values given in brackets) and SRMs between baseline and follow-up measurements for participants with different KLGs

Healthy reference (KLG0), MC (%)SRMOA participants (KLG2), MC (%)SRMKLG3, MC (%)SRM
LS mJSW0.0 (−0.1)−0.01−0.09 (−2.2)−0.30−0.29 (−7.4)†††−0.68**
FF mJSW0.03 (0.6)0.110.07 (1.7)0.17−0.05 (−1.3)−0.13
MFTC0.01 (0.2)0.06−0.01 (−0.3)−0.09−0.03 (−0.9)−0.18
cMFTC0.01 (0.1)0.04−0.03 (−0.7)−0.14−0.09 (−2.0)−0.32
MT0.0 (0.0)0.01−0.01 (−0.8)−0.230.0 (0.1)0.04
cMT0.0 (−0.1)−0.02−0.03 (−1.6)−0.29−0.01 (−0.5)−0.09
eMT0.0 (−0.3)−0.1−0.03 (−2.0)−0.35−0.03 (−2.4)−0.23
iMT0.01 (0.8)0.2−0.02 (−1.1)−0.20.0 (0.2)0.04
aMT0.0 (−0.3)−0.050.0 (0.2)0.050.02 (1.6)0.24
pMT0.0 (0.0 0)0.010.0 (0.3)0.050.02 (1.3)0.30
cMF0.01 (0.4)0.080.0 (0.1)0.03−0.03 (−1.8)−0.28
ccMF0.01 (0.4)0.060.0 (0.2)0.02−0.07 (−3.7)†−0.39*
ecMF0.01 (0.9)0.190.01 (0.9)0.13−0.03 (−2.4)−0.24
icMF0.0 (0.0)−0.01−0.01 (−0.4)−0.090.01 (0.5)0.11
LFTC0.02 (0.4)0.160.02 (0.6)0.150.03 (0.8)0.28
cLFTC0.02 (0.4)0.13−0.01 (−0.1)−0.020.04 (0.8)0.2
LT0.0 (0.0)0.00−0.01 (−0.3)−0.080.0 (0.2)0.06
cLT0.0 (0.1)0.02−0.03 (−1.1)−0.190.0 (0.0)0.0 0
eLT0.01 (0.5)0.130.03 (1.7)0.40*0.0 (−0.3)−0.06
iLT−0.01 (−0.5)−0.12−0.02 (−1.3)−0.250.01 (0.4)0.09
aLT0.0 (−0.2)−0.04−0.03 (−1.8)−0.330.04 (2.5)†0.4*
pLT0.0 (0.2)0.040.03 (1.4)0.27−0.03 (−1.4)−0.31
cLF0.02 (0.9)0.23*0.03 (1.7)0.280.03 (1.5)0.34
ccLF0.02 (0.9)0.190.03 (1.2)0.150.04 (1.9)0.32
ecLF0.01 (1.0)0.20.03 (1.7)0.310.02 (1.6)0.32
icLF0.01 (0.9)0.22*0.04 (2.3)0.380.02 (1.1)0.22
  • *p<0.05, **p<0.01, ***p<0.001 for change between baseline and follow-up examination; †p<0.05, ††p<0.01, †††p<0.001 for differences in changes between KLG2 vs KLG0 and KLG3 vs KLG0, respectively.

  • a, anterior; c, central; cLF, central weight-bearing lateral femoral condyle; cLFTC, central LFTC (cLT+ccLF); cMF, central weight-bearing medial femoral condyle; cMFTC, central MFTC (cMT+ccMF); e, external; FF, fixed flexion radiography; i, internal; KLG, Kellgren–Lawrence grade; LFTC, lateral femorotibial compartment; LS, Lyon–Schuss radiography; LT, lateral tibia; MFTC, medial femorotibial compartment; mJSW, minimum joint space width; MT, medial tibia; OA, osteoarthritis; p, posterior ; SRM, standardised response mean (mean change/standard deviation of the change); ThCtAB, total area of subchondral bone.