Table 2

Results for 6 months follow-up using MRI: mean annualised change (MC) in cartilage thickness (ThCtAB) in mm (percentage of the baseline values given in brackets) and SRMs between baseline and follow-up measurements for participants with different KLGs

Healthy reference (KLG0), MC (%)SRMOA participants (KLG2), MC (%)SRMKLG3, MC (%)SRM
MFTC−0.03 (−0.8)−0.180.07 (2.2)†0.31−0.04 (−1.2)−0.14
cMFTC−0.07 (−1.8)−0.31**0.11 (2.7)†0.28−0.16 (−3.7)−0.33
MT−0.01 (−0.8)−0.150.01 (0.6)0.08−0.03 (−1.9)−0.23
cMT−0.05 (−2.1)−0.25*0.04 (2.0)0.18−0.08 (−3.4)−0.29
eMT−0.01 (−0.7)−0.09−0.01 (−0.9)−0.13−0.05 (−3.9)−0.19
iMT−0.02 (−1.0)−0.13−0.02 (−0.8)−0.07−0.04 (−2.4)−0.26
aMT−0.01 (−0.8)−0.090.01 (0.8)0.06−0.02 (−1.5)−0.13
pMT0.02 (1.1)0.150.01 (1.0)0.110.02 (1.4)0.15
cMF−0.01 (−0.7)−0.120.06 (3.7)††0.46*−0.01 (−0.6)−0.05
ccMF−0.03 (−1.4)−0.150.07 (3.4)0.26−0.08 (−4.0)−0.30
ecMF−0.01 (−0.4)−0.060.04 (2.8)0.260.01 (0.8)0.06
icMF−0.01 (−0.4)−0.050.09 (4.7)††0.58**0.04 (1.9)0.17
LFTC0.04 (1.0)0.190.08 (2.0)0.46*0.06 (1.6)0.38
cLFTC0.07 (1.3)0.180.07 (1.3)0.220.05 (1.0)0.23
LT0.01 (0.5)0.09−0.02 (−1.1)−0.310.01 (0.3)0.05
cLT0.04 (1.3)0.15−0.05 (−1.8)−0.23−0.03 (−1.1)−0.13
eLT0.01 (0.5)0.070.04 (2.2)0.290 (0.1)0.01
iLT−0.01 (−0.8)−0.09−0.07 (−4.0)†−0.72***0.03 (1.8)0.24
aLT0.02 (1.3)0.150.0 (0.3)0.030.03 (2.1)0.2
pLT0.0 (−0.1)−0.01−0.02 (−1.0)−0.11−0.01 (−0.4)−0.04
cLF0.03 (1.5)0.22*0.1 (5.6)†0.66**0.05 (3.1)0.44*
ccLF0.03 (1.3)0.150.12 (5.6)0.49*0.08 (3.9)0.48*
ecLF0.04 (2.5)0.29**0.08 (4.9)0.48*0.06 (4.2)0.46*
icLF0.02 (0.9)0.130.1 (6.2)†0.59**0.02 (1.1)0.13
  • *p<0.05, **p<0.01, ***p<0.001 for change between baseline and follow-up examination; †p<0.05, ††p<0.01, †††p<0.001 for differences in changes between KLG2 vs KLG0 and KLG3 vs KLG0, respectively.

  • a, anterior; c, central; cLF, central weight-bearing lateral femoral condyle; cLFTC, central LFTC (cLT+ccLF); cMF, central weight-bearing medial femoral condyle; cMFTC, central MFTC (cMT+ccMF); e, external; i, internal; KLG, Kellgren–Lawrence grade; LFTC, lateral femorotibial compartment; LT, lateral tibia; MFTC, medial femorotibial compartment; MT, medial tibia; p, posterior ; OA, osteoarthritis; SRM, standardised response mean (mean change/standard deviation of the change); ThCtAB, total area of subchondral bone.