Variable | Baseline | 10-Year follow-up | p Value* |
Calprotectin (mg/l) | 2.2 (1.1–4.2) | 1.8 (0.85–3.3) | 0.006 |
Micro-CRP (mg/l) | 4.9 (1.9–12.3) | 3.7 (1.4–9.5) | 0.035 |
ESR (mm/h) | 20 (10–38) | 14 (8–24) | <0.001 |
Anti-CCP | 47 (4–222) | 44 (3–251) | 0.83 |
IgA RF | 13 (4–41) | 13 (3–30) | 0.16 |
IgM RF | 20 (5–107) | 28 (5–105) | 0.78 |
HAQ | 0.88 (0.38–1.34) | 0.88 (0.25–1.38) | 0.66 |
Van der Heijde modified Sharp score | 2 (0–8) | 23 (4–62) | <0.001 |
RAAD | Not tested | 5 (2–14) |
*Wilcoxon signed rank test of changes between baseline and follow-up.
Anti-CCP, antibodies to cyclic citrullinated peptide; CRP, C-reactive protein; ESR, erythrocyte sedimentation rate; HAQ, Health Assessment Questionnaire; RAAD, Rheumatoid Arthritis Articular Damage; RF, rheumatoid factor.