Table 4 Frequency of genotypes in Research Registry for Neonatal Lupus (RRNL) mothers studied followed for at least 3 years*
Allelic frequencyp Value†Genotypic frequencyp Value†
IL1α –889C/T (n = 43):
DiagnosisCTC/CC/TT/T
Asymptomatic to asymptomatic, pauci-UAS and SS (n = 10)1640.756401.0
Initial or progression to SLE (n = 33)491718132
TGFβ 869T/C (n = 55):
DiagnosisCTC/CT/CT/T
Asymptomatic to asymptomatic, pauci-UAS and SS (n = 14)16120.034820.03
Initial or progression to SLE (n = 41)275561520
TNFα −308G/A (n = 58):
DiagnosisGAG/GG/AA/A
Asymptomatic to asymptomatic, pauci-UAS and SS (n = 15)20100.451000.5
Initial or progression to SLE (n = 43)493710294
  • The genotype frequencies calculated for interleukin (IL)1α –889C/T, transforming growth factor (TGF)β 869T/C and tumour necrosis factor (TNF)α −308G/A were CC+CT vs TT, CC+TC vs TT, AA+GA vs GG, respectively. In addition, these three polymorphisms were compared to historical controls, there was an increased frequency of the IL1α –889(C/C) in systemic lupus erythematosus (SLE) (32% vs 55%, respectively, p = 0.017), TGFβ 869(T/T) in SLE (49% vs 35% to 40%, respectively, p = not significant) and −308A allele of TNFα (AA+GA vs GG) in SLE (24% vs 77%, respectively; p<0.001).6 9 3032 Comparisons between the groups were performed by Fisher exact test. p<0.05 was considered significant.

  • *Only Caucasian mothers were included in this analysis; †p values for comparison of mothers with SLE vs asymptomatic mothers.

  • SS, Sjögren syndrome, UAS, undifferentiated autoimmune syndrome.