Median (interquartile range) for semiquantitative and quantitative MRI measurements of the medial tibiofemoral joint in men
| K/L 0 (n = 322) | Subset of K/L 0 with no cartilage lesions on MRI (n = 169) | K/L 1 (n = 9) | K/L 2 (n = 32) | K/L 3 (n = 21) | K/L 4 (n = 12) | |
| Medial tibia | ||||||
| Volume, mm3 | 2527 (2216–2815) | 2520 (2240–2787) | 2859 (2342–2900) | 2519 (2415–2945) | 2278 (1917–2571) | 1394 (1190–1677) |
| p Value | 0.19 | 0.29 | 0.04 | <0.001 | ||
| Subchondral bone area, cm2 | 13.66 (12.88–14.65) | 13.63 (12.93–14.56) | 14.59 (13.24–15.51) | 14.50 (13.63–15.06) | 14.29 (13.58–15.47) | 13.86 (12.52–15.89) |
| p Value | 0.09 | 0.004 | 0.05 | 0.74 | ||
| Thickness, mm | 1.87 (1.72–1.99) | 1.87 (1.72–1.98) | 1.85 (1.79–1.96) | 1.82 (1.65–1.97) | 1.59 (1.32–1.83) | 0.99 (0.84–1.19) |
| p Value | 0.96 | 0.27 | 0.003 | <0.001 | ||
| WORMS score | 0.0 (0.0–0.0) | 0* | 1.0 (1.0–1.7) | 0.8 (0.3–1.5) | 3.3 (1.0–3.7) | 3.2 (1.0–5.3) |
| p Value | 0.001 | <0.001 | <0.001 | <0.001 | ||
| Central medial tibia‡ | ||||||
| Thickness, mm | 2.53 (2.28–2.73) | 2.54 (2.26–2.73) | 2.51 (2.31–2.67) | 2.32 (2.04–2.60) | 2.07 (1.70–2.41) | 0.85 (0.54–1.17) |
| p Value | 0.65 | 0.007 | <0.001 | <0.001 | ||
| WORMS score | 0.0 (0.0–0.0) | 0* | 2.5 (0.0–4.0) | 3.0 (3.0–4.0) | 5.0 (3.5–6.0) | 6.0 (5.0–6.0) |
| p Value | 0.001 | <0.001 | <0.001 | <0.001 | ||
| Central medial femur | ||||||
| Volume, mm3 | 1316 (1154–1523) | 1321 (1166–1502) | 1378 (1191–1639) | 1141 (1018–1417) | 823 (641–1252) | 361 (336–538) |
| p Value | 0.72 | 0.06 | <0.001 | <0.001 | ||
| Subchondral bone area, cm2 | 6.09 (5.41–6.81) | 6.09 (5.41–6.62) | 6.81 (5.19–7.04) | 5.97 (5.28–6.99) | 6.49 (5.83–6.92) | 5.89 (5.68–7.61) |
| p Value | 0.40 | 0.83 | 0.18 | 0.56 | ||
| Thickness, mm | 2.05 (1.86–2.24) | 2.05 (1.88–2.22) | 2.06 (1.83–2.19) | 1.90 (1.62–2.10) | 1.40 (0.90–1.57) | 0.63 (0.42–1.01) |
| p Value | 0.72 | 0.06 | <0.001 | <0.001 | ||
| WORMS score | 0.0 (0.0–2.0) | 0* | 2.0 (0.0–3.0) | 3.0 (3.0–4.0) | 5.0 (5.0–6.0) | 6.0 (6.0–6.0) |
| p Value | 0.005 | <0.001 | <0.001 | <0.001 | ||
| Central part of central medial femur†,‡ | ||||||
| Thickness, mm | 2.54 (2.20–2.82) | 2.54 (2.25–2.79) | 2.44 (2.11–2.57) | 2.13 (1.94–2.56) | 1.45 (0.90–1.73) | 0.34 (0.10–0.85) |
| p Value | 0.26 | 0.001 | <0.001 | <0.001 |
p Values from Wilcoxon test are printed in italics, and all of these p values are compared with Kellgren/Lawrence (K/L) grade 0. All data are presented with the focus on K/L 2 versus 0 depicted in bold font. *By definition this group has cartilage whole-organ magnetic resonance imaging score (WORMS) 0. †No corresponding WORMS score. ‡No corresponding volume measurement.