Table 2 Mothers by initial diagnosis, and their progression (n = 229), group II: mothers enrolled >1 year after birth of a neonatal lupus (NL)-affected child (n = 126)
Initial diagnosis at enrolmentn1*n2†Diagnosis after follow-upnMean time to diagnosisMean follow-up (years)CHB‡Rash§Time from birth to latest follow-up
Asymptomatic2919Asymptomatic114.91019
Pauci-UAS111.5103.2
Probable SS248.12011
Definite SS237.52010
SLE2810.62012
SLE/SS1510.51014
Pauci-UAS2317Pauci-UAS104.5829
Poly-UAS314.5307
Probable SS145.71020.2
SLE269.72012
SLE/SS123.81010.9
Poly-UAS127Poly-UAS43.63113
Probable SS138.30110.2
SLE/SS2310.22012
Probable SS3521Probable SS165.511513
Definite SS1271012
SLE/SS434.5229
Definite SS1313Definite SS114.79215
SLE/SS278.12012
SLE3222SLE226.216613
SLE/SS3927SLE/SS4.421615
  • The maternal mean age at the birth of the NL child was 30 years in both groups (16–44 years). The ethnic distribution was: 74.1% Caucasian, 9.7% African–American, 8.4% Hispanic, 5.0% Asian and 2.8% unknown/unanswered. Of 229 mothers studied, 171 had at least 1 NL child with CHB and 58 only had an NL rash child.

  • *n1, Total number of mothers who enrolled with specific diagnoses; †n2, mothers who were followed for at least 6 months; ‡CHB, mothers who had a child with congenital heart block (CHB), or a child with CHB+rash; §rash, mothers who had a child with NL rash only.

  • SLE, systemic lupus erythematosus; SS, Sjögren syndrome; UAS, undifferentiated autoimmune syndrome.