Median (interquartile range) for semiquantitative and quantitative MRI measurements of the medial tibiofemoral joint in women
| K/L 0 (n = 398) | Subset of K/L 0 with no cartilage lesions on MRI (n = 235) | K/L 1 (n = 24) | K/L 2 (n = 49) | K/L 3 (n = 34) | K/L 4 (n = 10) | |
| Medial tibia | ||||||
| Volume, mm3 | 1684 (1498–1895) | 1660 (1507–1853) | 1737 (1499–1892) | 1870 (1675–2111) | 1772 (1381–2062) | 1263 (930–1540) |
| p Value | 0.84 | <0.001 | 0.60 | <0.001 | ||
| Subchondral bone area, cm2 | 10.59 (9.86–11.35) | 10.50 (9.86–11.28) | 10.43 (10.00–11.10) | 11.46 (10.87–11.97) | 11.43 (10.78–12.29) | 11.75 (10.76–12.89) |
| p Value | 0.71 | <0.001 | <0.001 | <0.001 | ||
| Thickness, mm | 1.60 (1.49–1.71) | 1.60 (1.49–1.71) | 1.62 (1.48–1.76) | 1.65 (1.52–1.85) | 1.50 (1.27–1.63) | 0.99 (0.67–1.19) |
| p Value | 0.65 | 0.08 | 0.005 | <0.001 | ||
| WORMS score | 0.0 (0.0–0.0) | 0* | 0.0 (0.0–1.0) | 1.0 (0.0–2.0) | 2.7 (2.0–3.7) | 4.0 (3.7–5.0) |
| p Value | <0.001 | <0.001 | <0.001 | <0.001 | ||
| Central medial tibia‡ | ||||||
| Thickness, mm | 2.13 (1.93–2.33) | 2.12 (1.93–2.31) | 2.08 (1.89–2.44) | 2.22 (1.83–2.44) | 1.73 (1.49–2.19) | 0.96 (0.29–1.52) |
| p Value | 0.85 | 0.38 | <0.001 | <0.001 | ||
| WORMS score | 0.0 (0.0–0.0) | 0* | 0.0 (0.0–3.0) | 3.0 (0.0–3.0) | 5.0 (3.0–5.0) | 5.0 (5.0–6.0) |
| p Value | 0.001 | <0.001 | <0.001 | <0001 | ||
| Central medial femur | ||||||
| Volume, mm3 | 832 (713–978) | 827 (700–945) | 888 (674–1076) | 863 (710–1072) | 706 (509–947) | 249 (206–531) |
| p Value | 0.64 | 0.20 | 0.002 | <0.001 | ||
| Subchondral bone area, cm2 | 4.81 (4.27–5.42) | 4.74 (4.20–5.32) | 5.03 (4.33–5.60) | 5.12 (4.54–6.05) | 5.26 (4.21–5.91) | 5.28 (4.48–5.74) |
| p Value | 0.20 | 0.007 | 0.15 | 0.31 | ||
| Thickness, mm | 1.65 (1.53–1.82) | 1.64 (1.53–1.78) | 1.58 (1.48–1.81) | 1.63 (1.41–1.83) | 1.30 (1.01–1.55) | 0.47 (0.35–1.13) |
| p Value | 0.46 | 0.30 | <0.001 | <0.001 | ||
| WORMS score | 0.0 (0.0–2.0) | 0* | 2.5 (0.0–3.0) | 3.0 (2.5–4.0) | 5.0 (4.0–5.0) | 6.0 (5.0–6.0) |
| p Value | 0.001 | <0.001 | <0.001 | <0.001 | ||
| Central part of central medial femur†,‡ | ||||||
| Thickness, mm | 2.00 (1.80–2.22) | 2.00 (1.78–2.18) | 1.83 (1.63–2.03) | 1.83 (1.49–2.14) | 1.29 (0.98–1.66) | 0.18 (0.06–1.13) |
| p Value | 0.03 | 0.006 | <0.001 | <0.001 |
p Values from Wilcoxon test are printed in italics, and all of these p values are compared with Kellgren/Lawrence (K/L) grade 0. All data are presented with the focus on K/L 2 versus 0 depicted in bold font. *By definition this group has cartilage whole-organ magnetic resonance imaging score (WORMS) 0. †No corresponding WORMS score. ‡No corresponding volume measurement.