Table 3 Radiographic progression across the European League Against Rheumatism (EULAR) states based on the 28-joint Disease Activity Score (DAS28) C-reactive protein (CRP) and DAS28 erythrocyte sedimentation rate (ESR) values: mean change from baseline to 12 months (AIM (Abatacept in Inadequate responders to Methotrexate) trial)
Radiographic assessmentEULAR responseAbatacept group (n = 328)Placebo group (n = 137)Combined group (n = 465)
CRPESRCRPESRCRPESR
Erosion scoreGood0.37 (1.13)0.37 (1.17)0.41 (1.15)0.10 (0.23)0.37 (1.13)0.35 (1.14)
Moderate0.72 (1.70)0.63 (1.56)1.48 (3.70)1.36 (3.50)0.98 (2.59)0.85 (2.34)
None0.68 (1.17)0.65 (1.12)1.16 (2.07)1.26 (2.29)0.97 (1.78)1.03 (1.94)
Joint space narrowing scoreGood0.44 (1.11)0.41 (1.17)0.86 (2.27)0.43 (0.84)0.47 (1.23)0.41 (1.16)
Moderate0.69 (1.80)0.59 (1.43)1.47 (2.86)1.34 (2.76)0.96 (2.25)0.82 (1.96)
None0.56 (1.26)1.00 (2.63)1.13 (1.96)1.35 (2.23)0.91 (1.73)1.22 (2.37)
Total scoreGood0.81 (1.93)0.77 (2.09)1.27 (3.31)0.53 (0.84)0.84 (2.06)0.76 (2.04)
Moderate1.41 (3.03)1.22 (2.60)2.94 (6.30)2.70 (6.03)1.94 (4.49)1.67 (4.01)
None1.25 (2.26)1.65 (3.39)2.29 (3.74)2.61 (4.13)1.88 (3.27)2.25 (3.86)
  • Data are mean (SD).