Table 2 Risk factors for incident BML in the knee

	Univariate analysis* (OR, 95% CI)	p Value	Multivariate analysis (OR, 95% CI)	p Value
“Large” or “very large” BML
Age at baseline (years)	0.99 (0.93 to 1.1)	0.9	1.0 (0.9 to 1.1)†	0.7
Gender (female vs male)	1.5 (0.7 to 3.3)	0.3	1.66 (0.7 to 3.8)‡	0.2
BMI at baseline (kg/m²)	1.15 (1.0 to 1.2)	0.002	1.15 (1.06 to 1.2)§	0.001
“Very large” BML
Age at baseline (years)	0.97 (0.9 to 1.1)	0.6	0.99 (0.9 to 1.1)†	0.99
Gender (female vs male)	0.98 (0.3 to 3.1)	0.97	0.9 (0.3 to 3.1)‡	0.9
BMI at baseline (kg/m²)	1.24 (1.1 to 1.4)	<0.001	1.2 (1.1 to 1.4)§	0.001

*Odds ratio (OR) for an incident bone marrow lesion (BML) at follow-up per unit increase in respective variable. †OR for an incident BML at follow up per 1-year increase in age adjusted for gender and body mass index (BMI). ‡OR for an incident BML at follow-up when female = 1 adjusted for age and BMI. §OR for an incident BML at follow-up per unit increase in BMI adjusted for age and gender.