Table 1 Change in cartilage morphology (in the right knee) over 1 year for the total subcohort, and for women and men, respectively
All (n = 156)Women (n = 79)Men (n = 77)
MC%SRMp ValueMC%SRMp ValueMC%SRMp Value
MTVC−0.42−0.120.13−0.40−0.130.25−0.44−0.120.28
ThCtAB−0.52−0.160.04*−0.46−0.140.22−0.58−0.180.11
ThCcAB−0.34−0.120.14−0.23−0.080.47−0.44−0.150.19
cAB−0.19−0.110.19−0.31−0.140.22−0.11−0.070.56
cMFVC−1.49−0.210.008*−1.14−0.180.12−1.74−0.250.03*
ThCtAB−1.92−0.30<0.001*−1.69−0.260.02*−2.12−0.340.004*
ThCcAB−1.46−0.260.002*−1.34−0.230.047*−1.56−0.280.02*
cAB−0.47−0.120.14−0.20−0.060.61−0.69−0.170.15
MFTCVC−0.79−0.220.007*−0.66−0.190.10−0.88−0.250.03*
ThCtAB−1.23−0.31<0.001*−1.08−0.260.03*−1.37−0.370.002*
LTVC−0.55−0.170.03*−0.55−0.140.21−0.55−0.200.08
ThCtAB−0.68−0.230.005*−0.76−0.210.07−0.60−0.270.02*
ThCcAB−0.60−0.210.009*−0.68−0.190.09−0.52−0.240.04*
cAB0.030.020.780.150.110.32−0.06−0.050.67
cLFVC0.020.010.950.670.130.27−0.42−0.110.33
ThCtAB0.090.020.770.600.130.26−0.35−0.110.35
ThCcAB0.130.030.670.700.150.18−0.37−0.120.30
cAB0.010.000.95−0.06−0.040.750.060.030.77
LFTCVC−0.33−0.120.14−0.09−0.020.83−0.50−0.210.07
ThCtAB−0.30−0.110.17−0.10−0.030.80−0.48−0.230.046*
  • cAB, cartilage-covered bone area; cLF, weight-bearing lateral femoral condyle; cMF, weight-bearing medial femoral condyle; LFTC, lateral femoro-tibial compartment; LT, lateral tibia; MC%, mean change (in %); MFTC, medial femoro-tibial compartment; MT, medial tibia; SRM, standardised response mean (mean change/SD of change); ThCcAB, thickness of the cartilage over the entire cAB; ThCtAB, thickness of the cartilage over the entire subchondral bone area; VC, volume of cartilage.

  • *p Values <0.05 for paired t test between baseline and 1 year, without correcting for multiple testing, showing that the rate of loss was significantly different from zero.