Table 3 Adverse drug reactions (ADRs) leading to withdrawal and total ADR reported
ADRAllopurinol(n = 30)Benzbromarone(n = 25)
Number of patients with ADR2 (7%)/2 (7%)3(12%)/5 (20%)
    95% CI1–22%/1–22%3–31%/7–40%
Type of ADR
    Dizziness and flushing–/–1 (4%)/1 (4%)
    Gastrointestinal–/–2 (8%)/2 (8%)
    Hepatitis*–/––/–
    Gout flares–/––/1 (4%)
    INR increase–/––/1 (4%)
    Rash/skin reactions2 (7%)/2 (7%)–/–
        Severe skin reactions–/––/–
  • ADRs expressed as ADR leading to withdrawal (n (%))/total ADRs (n (%)) reported; one patient could report more than one ADR.

  • *Grade 2, 3 or 4 liver enzyme increases.