Table 4 Comparison of the corticosteroid and immunosuppressant mean doses expressed per year of follow-up as a function of the time infections occurred
Time after WG diagnosis for patients with severe infectionp Value
⩽3 years (n = 27)>3 years (n = 26)
Cumulated WG prior to infection treatment:
CYC (g/year)12.3 (13.4)3.4 (4)<0.05
Intravenous CYC (g/year)5.5 (3.9)1.3 (1.4)<0.001
Oral CYC (g/year)6.8 (12.5)2.2 (3.7)<0.05
CS (g/year)6.22 (4.72)3.11 (1.82)<0.001
AZA (g/year)2.8 (9.7)6.4 (19.6)
MTX (g/year)18.5 (94.1)41.3 (66.1)
Current WG treatment at time of infection:
MPS11
Oral CS (mg/day)
    >2017/27 (63%)7/26 (27%)<0.05
    ⩽207/27 (26%)14/26 (54%)<0.05
Intravenous CYC (mg/day)311 (491)77 (272)<0.05
Oral CYC (mg/day)25 (49)27 (62)
  • Results are expressed as mean (SD) or n (%).

  • AZA, azathioprine; CS, corticosteroid; CYC, cyclophosphamide; MPS, 1-3 methyl-prednisolone; MTX, methotrexate.