Table 2 Distribution of genotypes of the HS1,2A polymorphism in patients with early rheumatoid arthritis (ERA), patients with longstanding rheumatoid arthritis (LSRA) and controls

HS1,2A polymorphism genotype n (%)	Controls(n = 248)n (%)	Patients with ERA(n = 100)n (%)	OR (95% CI)	p Value*	Patients with LSRA(n = 114)n (%)	OR (95% CI)	p Value*
1/1	52 (21.0)	11 (11.0)	0.47 (0.23 to 0.94)	0.03	10 (8.8)	0.36 (0.18 to 0.74)	0.004
2/2	37 (14.9)	27 (27.0)	2.11 (1.20 to 3.70)	0.008	39 (34.2)	2.96 (1.76 to 5.00)	<0.001
3/3	2 (0.8)	–	0.49 (0.02 to 10.32)	1.00	–	0.43 (0.02 to 9.05)	1.00
4/4	4 (1.6)	5 (5.0)	3.21 (0.84 to 12.22)	0.13	–	0.24 (0.01 to 4.45)	0.31
1/2	84 (33.9)	46 (46.0)	1.66 (1.04 to 267)	0.03	59 (51.8)	2.09 (1.33 to 3.29)	0.001
1/3	12 (4.8)	3 (3.0)	0.61 (0.17 to 2.20)	0.57	–	0.08 (0.00 to 1.49)	0.02
1/4	18 (7.3)	2 (2.0)	0.26 (0.06 to 1.15)	0.07	–	0.05 (0.00 to 0.91)	0.001
2/3	13 (5.2)	1 (1.0)	0.18 (0.02 to 1.42)	0.08	3 (2.6)	0.90 (0.14 to 1.75)	0.40
2/4	25 (10.1)	5 (5.0)	0.47 (0.17 to 1.26)	0.14	3 (2.6)	0.24 (0.07 to 0.82)	0.014
3/4	1 (0.4)	–	0.83 (0.03 to 20.34)	1.00	–	0.72 (0.03 to 17.84)	1.00

*p Values are calculated from χ² tests performed in patients (ERA and LSRA) versus controls.