Figure 3

Gout and osteoarthritis. (A) Data from the Vet-QOL survey from veterans with gout and comorbidities (red) versus US norms (light purple polygon), “treatment failure gout” patients enrolled in the longitudinal observational Natural History Study (NHS); (yellow polygon; A/G norms: purple polygon) and treatment failure gout patients enrolled in two phase 3 protocols comparing pegloticase (PGL) versus placebo (dark purple). Short Form-6D (SF-6D) values confirm the impact of chronic gout on health-related quality of life (HRQOL), remarkably similar across these populations. (B) Spydergrams of baseline Short Form-36 (SF-36) scores in individuals with knee osteoarthritis in a randomised controlled trial (RCT) compared with US subjects with a mean age of 59.7 years with hypertension (HTN) and angina, demonstrating that knee osteoarthritis (OA) more profoundly affects physical HRQOL, particularly physical function (PF) and bodily pain (BP), whereas cardiovascular disease has more profound effects on general health perceptions (GH) and vitality (VT) domains. BL, baseline; VAH, Veterans Affairs Hospitals.