| Category | Questions |
| Cyclophosphamide | Is cyclophosphamide beneficial in interstitial lung disease in SSc? |
| Does cyclophosphamide have beneficial effects on organ manifestations other than interstitial lung disease in SSc? | |
| What is the optimal timing to initiate cyclophosphamide in SSc? | |
| Prostacyclins | Do prostacyclin analogues have beneficial effects on digital vasculopathy in SSc? |
| Do prostacyclin analogues have beneficial effects on pulmonary arterial hypertension in SSc? | |
| Endothelin receptor antagonists | Do endothelin receptor antagonists have beneficial effects on digital vasculopathy in SSc? |
| Do endothelin receptor antagonists have beneficial effects on pulmonary arterial hypertension in SSc? | |
| Selective PDE inhibitors | Do selective PDE inhibitors have beneficial effects on digital vasculopathy in SSc? |
| Do selective PDE inhibitors have beneficial effects on pulmonary arterial hypertension in SSc? | |
| Do selective PDE inhibitors have beneficial effects on erectile dysfunction in SSc? | |
| Corticosteroids | Are steroids beneficial in SSc? |
| What evidence exists that steroids induce scleroderma renal crisis? | |
| Stem cell transplantation | Does haematopoietic stem cell transplantation have beneficial effects in SSc? |
| ACE inhibitors and angiotensin receptor antagonists (sartans) | Do ACE inhibitors have beneficial effects in SSc? |
| Do angiotensin receptor antagonists (Sartans) have beneficial effects in SSc? | |
| Immunosuppressive drugs | Is there any evidence of beneficial effects of ciclosporin A in SSc? |
| Is there any evidence of beneficial effects of mycophenolate mofetil in SSc? | |
| Is there any evidence of beneficial effects of methotrexate in SSc? | |
| Is there any evidence of beneficial effects of azathioprine in SSc? | |
| Calcium channel blockers | Do calcium channel blockers have beneficial effects on digital vasculopathy in SSc? |
| Do calcium channel blockers have beneficial effects on PAH in SSc? | |
| Proton pump inhibitors | Is there any evidence for beneficial effects of proton pump inhibitors on oesophageal involvement in SSc? |
| Other treatments | Is there any evidence for efficacy of prokinetic drugs (clebopride, mosapride, erythromycin, octreotide, misoprostol, metoclopramide, domperidone, cisapride, etc.) in SSc oesophageal, stomach and intestinal involvement? |
| Which drugs are beneficial in subcutaneous calcinosis in SSc? | |
| Is there a place for antibiotics in the treatment of symptomatic gastrointestinal disease in SSc? | |
| Is there any evidence that NSAIDs are harmful in SSc? |
ACE, angiotensin converting enzyme; NSAIDs, non-steroidal anti-inflammatory drugs; PDE, phosphodiesterase; SSc, systemic sclerosis.