Table 2 Final research questions
CategoryQuestions
CyclophosphamideIs cyclophosphamide beneficial in interstitial lung disease in SSc?
Does cyclophosphamide have beneficial effects on organ manifestations other than interstitial lung disease in SSc?
What is the optimal timing to initiate cyclophosphamide in SSc?
ProstacyclinsDo prostacyclin analogues have beneficial effects on digital vasculopathy in SSc?
Do prostacyclin analogues have beneficial effects on pulmonary arterial hypertension in SSc?
Endothelin receptor antagonistsDo endothelin receptor antagonists have beneficial effects on digital vasculopathy in SSc?
Do endothelin receptor antagonists have beneficial effects on pulmonary arterial hypertension in SSc?
Selective PDE inhibitorsDo selective PDE inhibitors have beneficial effects on digital vasculopathy in SSc?
Do selective PDE inhibitors have beneficial effects on pulmonary arterial hypertension in SSc?
Do selective PDE inhibitors have beneficial effects on erectile dysfunction in SSc?
CorticosteroidsAre steroids beneficial in SSc?
What evidence exists that steroids induce scleroderma renal crisis?
Stem cell transplantationDoes haematopoietic stem cell transplantation have beneficial effects in SSc?
ACE inhibitors and angiotensin receptor antagonists (sartans)Do ACE inhibitors have beneficial effects in SSc?
Do angiotensin receptor antagonists (Sartans) have beneficial effects in SSc?
Immunosuppressive drugsIs there any evidence of beneficial effects of ciclosporin A in SSc?
Is there any evidence of beneficial effects of mycophenolate mofetil in SSc?
Is there any evidence of beneficial effects of methotrexate in SSc?
Is there any evidence of beneficial effects of azathioprine in SSc?
Calcium channel blockersDo calcium channel blockers have beneficial effects on digital vasculopathy in SSc?
Do calcium channel blockers have beneficial effects on PAH in SSc?
Proton pump inhibitorsIs there any evidence for beneficial effects of proton pump inhibitors on oesophageal involvement in SSc?
Other treatmentsIs there any evidence for efficacy of prokinetic drugs (clebopride, mosapride, erythromycin, octreotide, misoprostol, metoclopramide, domperidone, cisapride, etc.) in SSc oesophageal, stomach and intestinal involvement?
Which drugs are beneficial in subcutaneous calcinosis in SSc?
Is there a place for antibiotics in the treatment of symptomatic gastrointestinal disease in SSc?
Is there any evidence that NSAIDs are harmful in SSc?
  • ACE, angiotensin converting enzyme; NSAIDs, non-steroidal anti-inflammatory drugs; PDE, phosphodiesterase; SSc, systemic sclerosis.