| Location | Baseline mean (SD) | No. (%) of participants with denuded area at baseline | Mean change (SD) from model | SRM | Mean change in knees with K&L = 2 or 3(SD) n = 116 | Mean change in knees with K&L = 2–4 and varus angulation (SD) n = 59 |
| Femur | 176.64 (241.21) | 124 (82.7) | 8.97 (37.26) | 0.241 | 17.58 (48.80) | 8.38 (58.75) |
| Lat Tibia | 6.91 (28.06) | 55 (36.7) | 0.96 (9.22) | 0.104 | 0.63 (11.73) | −0.48 (6.21) |
| Med Tibia | 44.16 (109.13) | 69 (46.0) | 2.06 (21.62) | 0.095 | 2.38 (17.72) | 3.44 (21.34) |
| Patella | 97.71 (208.50) | 81 (54.0) | −1.64 (30.47) | −0.054 | −0.60 (35.10) | −3.54 (28.18) |
| Trochlea | 99.07 (198.43) | 89 (59.3) | 1.14 (23.48) | 0.049 | 9.88 (41.67) | −0.25 (46.49) |
| Cent Lat Femur | 4.03 (18.15) | 84 (56.0) | 0.65 (5.48) | 0.118 | 0.77 (6.12) | 0.63 (2.55) |
| Cent Lat Tibia | 4.57 (24.51) | 89 (59.3) | 0.76 (8.93) | 0.085 | 0.78 (10.68) | −0.86 (4.97) |
| Cent Med Femur | 60.88 (128.69) | 93 (62.0) | 6.47 (27.08) | 0.239 | 6.64 (22.24) | 8.35 (33.63) |
| Cent Med Tibia | 43.28 (107.76) | 90 (60.0) | 1.79 (19.36) | 0.092 | 2.17 (16.93) | 3.13 (20.80) |
| Post Lat Femur | 1.00 (6.19) | 7 (4.7) | 0.37 (2.82) | 0.131 | 0.41 (2.76) | 0.037 (0.12) |
| Post Med Femur | 8.76 (35.49) | 84 (56.0) | 0.16 (10.69) | 0.015 | 0.15 (9.91) | −0.15 (13.85) |
| Cent+Post Med Femur | 69.64 (147.74) | 94 (62.7) | 6.63 (30.88) | 0.215 | 6.79 (26.87) | 8.20 (38.07) |
| Cent+PostMedFemur+MedTibia | 113.81 (248.61) | 109 (72.7) | 8.69 (42.65) | 0.204 | 9.17 (37.50) | 11.64 (49.58) |
Cent, central; K&L, Kellgren and Lawrence (grade); Lat, lateral; Med, medial; Post, posterior; SRM, standardised response mean.
Percentage of change on denuded surface areas was not defined because some knees had zero baseline values and non-zero follow-up values.