Table 3 Genotype distribution and allele frequencies of the FAS−670G>A polymorphism in SSc patients, according to the autoantibody pattern*
Genotype or alleleAnti-Scl-70+ (n  =  118)Anti-Scl-70− (n  =  232)ACA+ (n  =  157)ACA− (n  =  193)
−670GG18 (15.2)47 (20.2)31 (19.8)34 (17.6)
−670GA56 (47.5)102 (44.0)69 (43.9)89 (46.1)
−670AA44 (37.3)83 (35.8)†57 (36.3)70 (36.3)§
−670G0.390.420.420.41
−670A0.610.58‡0.580.59¶

  • *Values are the number (%) of subjects with a given genotype and the frequency of the FAS–670 alleles in the different subgroups of SSc patients. p Values were calculated by χ2 analysis. †, ‡p  =  not significant, for comparison with the anti-Scl-70-positive subgroup. §, ¶p  =  not significant, for comparison with the ACA-positive subgroup. ACA, anticentromere antibodies; Anti-Scl-70, anti-topoisomerase I antibodies; SSc, systemic sclerosis.