Genotype or allele | Anti-Scl-70+ (n = 118) | Anti-Scl-70− (n = 232) | ACA+ (n = 157) | ACA− (n = 193) |
−670GG | 18 (15.2) | 47 (20.2) | 31 (19.8) | 34 (17.6) |
−670GA | 56 (47.5) | 102 (44.0) | 69 (43.9) | 89 (46.1) |
−670AA | 44 (37.3) | 83 (35.8)† | 57 (36.3) | 70 (36.3)§ |
−670G | 0.39 | 0.42 | 0.42 | 0.41 |
−670A | 0.61 | 0.58‡ | 0.58 | 0.59¶ |
*Values are the number (%) of subjects with a given genotype and the frequency of the FAS–670 alleles in the different subgroups of SSc patients. p Values were calculated by χ2 analysis. †, ‡p = not significant, for comparison with the anti-Scl-70-positive subgroup. §, ¶p = not significant, for comparison with the ACA-positive subgroup. ACA, anticentromere antibodies; Anti-Scl-70, anti-topoisomerase I antibodies; SSc, systemic sclerosis.