Table 2 Genotype distribution and allele frequencies of the FAS−670G>A polymorphism in control subjects, SSc patients and in the lcSSc and dcSSc clinical subsets*
Genotype or alleleControls (n  =  232)All SSc (n  =  350)lcSSc (n  =  259)dcSSc (n  =  91)
−670GG60 (25.9)65 (18.6)52 (20.1)13 (14.3)
−670GA120 (51.7)158 (45.1)117 (45.2)41 (45.0)
−670AA52 (22.4)127 (36.3)†90 (34.7)37 (40.7)§
−670G0.520.410.430.37
−670A0.480.59‡0.570.63¶
  • *Values are the number (%) of subjects with a given genotype and the frequency of the FAS–670 alleles in patients and controls. p Values were calculated by χ2 analysis. †χ2  =  13.45, p = 0.001, for comparison with the control group. ‡χ2  =  12.61, p = 0.001, for comparison with the control group. §χ2  =  1.86, p = 0.4, for comparison with the lcSSc group. ¶χ2  =  1.90, p = 0.2, for comparison with the lcSSc group. dcSSc, diffuse cutaneous SSc; lcSSc, limited cutaneous SSc; SSc, systemic sclerosis.