Table 3 Single nucleotide polymorphisms (SNPs) showing a nominal significant difference in allele frequencies between patients with rheumatoid arthritis (RA) and controls from the discovery set

Gene	SNP	MAF % (n/N)*		Odds ratio (95% CI)	p Value
Gene	SNP	Patients with RA	Controls	Odds ratio (95% CI)	p Value
IKBKB	rs9694958	7.0 (63/894)	9.9 (128/1296)	0.69 (0.51 to 0.95)	0.02
	rs2272733	7.9 (70/884)	12.5 (161/1292)	0.60 (0.45 to 0.81)	<0.001
	rs12676482	2.7 (24/892)	5.7 (74/1292)	0.46 (0.28 to 0.73)	<0.001
	rs17875732	5.0 (40/806)	9.1 (116/1268)	0.52 (0.36 to 0.75)	<0.001
	rs3136717	8.0 (72/896)	11.6 (147/1272)	0.67 (0.50 to 0.90)	0.007
IKBKE	rs17433909	1.6 (14/874)	3.9 (48/1244)	0.41 (0.22 to 0.74)	0.002
	rs2151222	31.7 (278/876)	27.7 (355/1280)	1.21 (1.00 to 1.46)	0.045
	rs17434047	0.9 (8/870)	2.5 (30/1208)	0.36 (0.17 to 0.80)	0.009
	rs3748022	25.2 (220/874)	21.0 (264/1258)	1.26 (1.03 to 1.55)	0.02
REL	rs6545835	22.1 (165/746)	27.0 (311/1152)	0.77 (0.62 to 0.95)	0.017
	rs842647	25.2 (222/880)	21.6 (277/1284)	1.23 (1.00 to 1.50)	0.047
	rs3732179	25.5 (225/882)	21.8 (280/1284)	1.23 (1.00 to 1.50)	0.045

*MAF, minor allele frequency; n/N, number of minor alleles/total number of alleles.