Mean values and SD of the original BASDAI, mini-BASDAI, patient global and BASFI in the GESPIC at baseline (N = 228) and the TNFα trial population (N = 91) in the total group as well as in subgroups without (“P−” group) and with peripheral involvement (“P+” group)
| AS population | Parameters | (1) All AS patients | (2) Subgroup without peripheral involvement (“P−” group)* | (3) Subgroup with peripheral involvement (“P+” group)† | Difference between groups (3) and (2)‡ | p Value |
| GESPIC (N = 228) | Original BASDAI, mean (SD) | 3.94 (2.06) | 3.62 (2.02) | 4.71 (2.00) | 1.09 (30.1%) | <0.001 |
| Mini-BASDAI, mean (SD) | 4.72 (2.12) | 4.54 (2.13) | 5.17 (2.05) | 0.63 (13.9%) | 0.038 | |
| Difference between mini-BASDAI and original BASDAI§ | 0.78 (19.8%) | 0.92 (25.4%) | 0.46 (9.8%) | NA | NA | |
| Patient global, mean (SD) | 5.04 (2.55) | 4.82 (2.58) | 5.58 (2.43) | 0.76 (15.8%) | 0.043 | |
| BASFI, mean (SD) | 3.20 (2.50) | 2.98 (2.46) | 3.73 (2.52) | 0.75 (25.2%) | 0.038 | |
| TNFα trial population (N = 91) | Original BASDAI, mean (SD) | 6.49 (1.23) | 6.08 (1.26) | 6.76 (1.15) | 0.68 (11.2%) | 0.005 |
| Mini-BASDAI, mean (SD) | 6.98 (1.25) | 6.70 (1.21) | 7.16 (1.25) | 0.46 (6.9%) | NS | |
| Difference between mini-BASDAI and original BASDAI§ | 0.49 (7.6%) | 0.62 (10.2%) | 0.40 (5.9%) | NA | NA | |
| Patient global, mean (SD) | 7.20 (1.73) | 6.83 (1.94) | 7.44 (1.56) | 0.61 (8.9%) | NS | |
| BASFI, mean (SD) | 6.23 (1.62) | 5.73 (1.30) | 6.56 (1.73) | 0.83 (14.5%) | 0.001 |
*“P−”, subgroup of ankylosing spondylitis (AS) patients without peripheral involvement at baseline, 70.6% in the German Spondyloarthritis Inception Cohort (GESPIC) and 39.6% in the tumour necrosis factor alpha (TNFα) trial population.
†“P+”, subgroup of AS patients with peripheral involvement at baseline, 29.4% in the GESPIC and 61.4% in the TNFα trial population.
‡Difference between groups 3 and 2 (absolute difference and percentage change, referring to group 2).
§Difference between the mini-Bath Ankylosing Spondylitis Disease Activity Index (BASDAI; without Q3arthritis and Q4enthesitis) and the original BASDAI (absolute difference and percentage change, referring to original BASDAI).
BASFI, Bath Ankylosing Spondylitis Functional Index; NA, not assessed; NS, non-significant (p⩾0.05).