Analysis of the vascular variables in relation to the presence or absence of HOA
| Men (n = 924) | Women (n = 1267) | |||
| Exploratory study (n = 2191) | Unadjusted | Adjusted† | Unadjusted | Adjusted† |
| Carotid plaque (moderate or higher) | 0.94 (0.7 to 1.27) | 0.9 (0.66 to 1.23) | 1.44 (1.12 to 1.85)** | 1.31 (1 to 1.73)* |
| Coronary calcifications (present/absent) | 1.22 (0.61 to 2.48) | 1.33 (0.64 to 2.76) | 1.69 (1.25 to 2.26)*** | 1.49 (1.08 to 2.05)* |
| History of stroke (yes/no) | 1.24 (0.77 to 1.99) | 1.16 (0.72 to 1.9) | 0.92 (0.58 to 1.46) | 0.84 (0.52 to 1.34) |
| History of cardiac events (yes/no) | 0.88 (0.64 to 1.2) | 0.91 (0.6 to 1.38) | 0.66 (0.42 to 1.02) | 0.55 (0.33 to 0.93)* |
| Means (normally distributed variables) | HOA/no HOA | HOA/no HOA | HOA/no HOA | HOA/no HOA |
| CCA-IMT (mm) (SE) | 1.01 (0.006)/1.01 (0.008) | 1.01 (0.006/1.01 (0.008) | 0.93 (0.007)/0.95 (0.005) | 0.95 (0.005)/0.94 (0.007) |
| Coronary calcifications (Agatston units (log)) (SE) | 5.92 (0.08)/5.91 (0.11) | 5.89 (0.09)/5.85 (0.11) | 4.44 (0.09)/3.82 (0.13)*** | 4.63 (0.09)/4.23 (0.12)** |
| Aortic calcifications (Agatston units (log)) (SE) | 7.38 (0.07)/7.31 (0.09) | 7.43 (0.07)/7.42 (0.09) | 7.41 (0.06)/7.12 (0.09)** | 7.58 (0.06)/7.52 (0.08) |
| Men (n = 1340) | Women (n = 1811) | |||
| Validation study (n = 3151) | Unadjusted | Adjusted† | Unadjusted | Adjusted† |
| Carotid plaque (moderate or higher) | 1.08 (0.83 to 1.41) | 1.1 (0.84 to 1.46) | 1.23 (0.98 to 1.53) | 1.2 (0.95 to 1.52) |
| Coronary calcifications (present/absent) | 0.93 (0.47 to 1.85) | 0.97 (0.48 to 1.97) | 1.25 (0.94 to 1.65) | 1.36 (1.01 to 4.09)* |
| History of stroke (yes/no) | 1.25 (0.84 to 1.85) | 1.31 (0.88 to 1.95) | 0.88 (0.61 to 1.27) | 0.84 (0.58 to 1.22) |
| History of cardiac events (yes/no) | 0.88 (0.67 to 1.15) | 0.88 (0.63 to 1.23) | 0.93 (0.64 to 1.33) | 0.87 (0.57 to 1.32) |
| Means (normally distributed variables) | Hosteoarthritis/no HOA | HOA/no HOA | HOA/no HOA | HOA/no HOA |
| CCA-IMT (mm) (SE) | 1.02 (0.005)/1.02 (0.007) | 1.02 (0.006)/1.02 (0.007) | 0.96 (0.004)/0.94 (0.006) | 0.97 (0.004)/0.96 (0.006) |
| Coronary calcifications (Agatston units (log)) (SE) | 6.04 (0.1)/6.01 (0.07) | 6.02 (0.07)/6.0 (0.1) | 4.53 (0.07)/4.29 (0.11) | 4.74 (0.07) (/4.5 (0.1)* |
| Aortic calcifications (Agatston units (log)) (SE) | 7.52 (0.06)/7.38 (0.08) | 7.56 (0.06)/7.39 (0.08) | 7.53 (0.05)/7.39 (0.07) | 7.71 (0.04)/7.63 (0.06) |
| Men (n = 2264) | Women (n = 3078) | |||
| AGES Reykjavik study (n = 5342) | Unadjusted | Adjusted† | Unadjusted | Adjusted† |
| Carotid plaque (moderate or higher) | 1.02 (0.84 to 1.24) | 1.02 (0.83 to 1.25) | 1.32 (1.12 to 1.55)** | 1.25 (1.04 to 1.49)* |
| Coronary calcifications (present/absent) | 1.06 (0.65 to 1.74) | 1.13 (0.67 to 1.83) | 1.44 (1.17 to 1.76)*** | 1.42 (1.14 to 1.76)** |
| History of stroke (yes/no) | 1.25 (0.92 to 1.69) | 1.25 (0.92 to 1.7) | 0.9 (0.67 to 1.19) | 0.85 (0.63 to 1.13) |
| History of cardiac events (yes/no) | 0.88 (0.72 to 1.08) | 0.88 (0.68 to 1.14) | 0.81 (0.61 to 1.07) | 0.71 (0.51 to 0.98)* |
| Means (normally distributed variables) | HOA/no HOA | HOA/no HOA | HOA/no HOA | HOA/no HOA |
| CCA-IMT (mm) (SE) | 1.01 (0.004)/1.02 (0.005) | 1.01 (0.004)/1.01 (0.005) | 0.95 (0.003)/0.94 (0.005) | 0.96 (0.003)/0.95 (0.004) |
| Coronary calcifications (Agatston units (log)) (SE) | 5.98 (0.05)/5.98 (0.07) | 5.96 (0.06)/5.95 (0.07) | 4.49 (0.06)/4.09 (0.08)*** | 4.69 (0.06)/4.38 (0.08)*** |
| Aortic calcifications (Agatston units (log)) (SE) | 7.46 (0.04)/7.35 (0.06) | 7.51 (0.05)/7.4 (0.06) | 7.48 (0.04)/7.27 (0.06)** | 7.66 (0.04)/7.57 (0.06) |
Unless otherwise indicated, values are odds ratios (95% CI).
*p<0.05, **p<0.01, ***p<0.001.
†Adjusted for age, smoking, cholesterol, triglycerides, body mass index, pulsepressure and statin use.
CCA-IMT, common carotid artery intima-media thickness; HOA, hand osteoarthritis.