Analysis of rs743777 and rs2104286 with rheumatoid arthritis (RA) in two populations of northern European descent
| N | Cases | MAF | N | Controls | MAF | OR (95% CI) | p Value | HW-controls | |||||
| 11 | 12 | 22 | 11 | 12 | 22 | ||||||||
| IL2RB rs743777 | |||||||||||||
| This study | 616 | 76 (0.12) | 288 (0.47) | 252 (0.41) | 0.36 | 544 | 58 (0.11) | 217 (0.40) | 269 (0.49) | 0.31 | 1.26 (1.06 to 1.50) | 0.009 | 0.377 |
| Validation study UK | 4680 | 532 (0.11) | 2031(0.43) | 2117 (0.45) | 0.33 | 11200 | 1040 (0.09) | 4832 (0.43) | 5328 (0.48) | 0.31 | 1.11 (1.05 to 1.17) | <0.001 | 0.501 |
| Combined | 1.12 (1.06 to 1.18) | 8.6×10−6 | |||||||||||
| IL2RA rs2104286 | |||||||||||||
| This study | 616 | 36 (0.06) | 226 (0.37) | 354 (0.57) | 0.24 | 545 | 54 (0.10) | 200 (0.37) | 291 (0.53) | 0.29 | 0.81 (0.67 to 0.98) | 0.026 | 0.100 |
| Validation study UK | 4660 | 312 (0.07) | 1740(0.37) | 2608 (0.56) | 0.24 | 11260 | 790 (0.07) | 4464 (0.40) | 6006 (0.53) | 0.28 | 0.93 (0.88 to 0.98) | 0.007 | 0.597 |
| Combined | 0.92 (0.87 to 0.97) | 0.001 | |||||||||||
Allele frequency data of RA cases versus controls was compared using a fixed effects (Mantel-Haenszel) meta-analysis. No significant heterogeneity or deviation from Hardy-Weinberg (HW) equilibrium was observed among the studies.