Table 7 Alternative remission induction treatments in relapsing, refractory or persistent disease
Intravenous immunoglobulin2 g/kg over 5 daysMuso et al, Jayne et al 77 78
15-Deoxyspergualin0.5 mg/kg/day till white cell count nadir of 3000/μl, then wait until the white cell count returns to ⩾ 4000/μl and repeat the dose for six cyclesBurke et al 79
Anti-thymocyte globulin2.5 mg/kg/day for 10 days adjusted according to lymphocyte count: no anti-thymocyte globulin if <150/μl, 1.5 mg/kg/day if 150–300/μl, full dose if >300/μlSchmitt et al 35
Infliximab3–5 mg/kg/infusion every 1 to 2 monthsBooth et al 80
Mycophenolate mofetil2 g/dayKoukoulaki et al, Stassen et al 74 81
Rituximab375 mg/m2 body surface area weekly for 4 weeksKeogh et al, Keogh et al, Stasi et al, Brihaye et al, Eriksson et al 82 86