Table 6 Dose modification of pulsed cyclophosphamide as used in a randomised controlled trial comparing the efficacy of daily oral versus pulsed cyclophosphamide for renal vasculitis (http://www.vasculitis.org/protocols/CYCLOPS.pdf)
Pulsed CYC dose reductions for renal function and age
Age, yearsCreatinine (μmol/litre)
<300300–500
<6015 mg/kg/pulse12.5 mg/kg/pulse
60–7012.5 mg/kg/pulse10 mg/kg/pulse
>7010 mg/kg/pulse7.5 mg/kg/pulse

  • The trial did not include a separate regimen for patients with a creatinine of <150 μmol/litre.

  • CYC, cyclophosphamide.