Table 5 European Vasculitis Study (EUVAS) disease categorisation of anti-neutrophilic cytoplasmic antibodies (ANCA)-associated vasculitis
LocalisedUpper and/or lower respiratory tract disease without any other systemic involvement or constitutional symptoms
Early systemicAny, without organ-threatening or life-threatening disease
GeneralisedRenal or other organ threatening disease, serum creatinine <500 μmol/litre (5.6 mg/dl)
SevereRenal or other vital organ failure, serum creatinine >500 μmol/litre (5.6 mg/dl)
RefractoryProgressive disease unresponsive to glucocorticoids and cyclophosphamide