Table 4

Risk of any fracture in patients with ankylosing spondylitis stratified by history of inflammatory bowel disease, psoriasis or hip/knee joint replacement, GP visit for back pain in the 6 months before, or use of NSAID’s or sulfasalazine in the 6 months before fracture

CharacteristicNo of casesNo of controlsCrude OR (95% CI)Adjusted OR* (95% CI)
History of IBD2063.32 (1.34 to 8.26)2.79 (1.10 to 7.08)
History of psoriasis26171.52 (0.83 to 2.80)1.23 (0.65 to 2.34)
Knee/hip joint replacement14160.88 (0.43 to 1.81)0.77 (0.37 to 1.62)
GP visit for back pain in previous 6 months72411.76 (1.20 to 2.58)1.33 (0.89 to 1.98)
Use of NSAIDs in previous 6 months1261221.03 (0.81 to 1.33)0.65 (0.50 to 0.84)
Use of sulfasalazine in previous 6 months790.78 (0.29 to 2.09)0.51 (0.19 to 1.41)
  • *Adjusted for medications and illnesses associated with risk of fracture (as outlined in the Methods section), and smoking and body mass index when known.

  • CI, confidence interval; IBD, inflammatory bowel disease; NSAID, non-steroidal anti-inflammatory drug; OR, odds ratio.