Table 1

Characteristics of fracture cases and controls

CharacteristicsFracture cases, n (%)(N = 231 436)Controls, n (%)(N = 231 362)p Value
Age (years)
    ⩽3051573 (22.3%)52140 (22.5%)NS
    31–4547948 (20.7%)47885 (20.7%)NS
    45–6040965 (17.7%)40906 (17.6%)NS
    ⩾6191292 (39.4%)90847 (39.2%)NS
Sex
    Male110163 (47.5%)110163 (47.5%)NS
    Female121615 (52.5%)121615 (52.5%)NS
Drug use in 6 months before index date
    Sulfasalazine564 (0.2%)447 (0.2%)<0.0005
    NSAIDs32209 (13.9%)21013 (9.1%)<0.0001
    Oral glucocorticoids9549 (4.1%)5264 (2.3%)<0.0001
    Hypnotics/anxiolytics22328 (9.6%)14466 (6.2%)<0.0001
Medical history
    IBD1134 (0.5%)896 (0.4%)<0.0005
    Psoriasis6373 (2.7%)4636 (2.0%)<0.0001
    Recent back pain (previous 6 months)19035 (8.2%)10362 (4.5%)<0.0001
    Joint replacement therapy4277 (1.8%)2946 (1.3%)<0.0001
  • IBD, inflammatory bowel disease; NS, not significant; NSAID, non-steroidal anti-inflammatory disease.