Table 4

Position mapped arthritis quantitative trait loci (QTLs) on Rattus norvegicus chomosome (RNO)4 and selected genes

QTLPosition (Mb)MarkerLOD*GeneGene name
Pia29, RNO4, 156.5 Mb155.1Cacna1cVoltage-dependent L-type calcium channel subunit α-1C
156.5D4Rat2014.27 2.86†
155.67Adipor2Adiponectin receptor 2
156.7D4Rat637.27 3.29†
156.74XR005442.1Similar to jumonji/ARID domain-containing protein 1A (JARID1A)
156.83Il17raInterleukin 17 receptor A
157.25D4Rat1134.38 2.59†
157.3BidBH3-interacting domain death agonist
Pia27b, RNO4, 157.9 Mb157.5Mical3Mical3 protein
157.74Slc6a13Na-dependent and Cl-dependent GABA transporter 2
158.1A2mα2 Macroglobulin precursor
158.15D4Rat625.67 1.07†
158.28Mug1Murinoglobulin-1 precursor (α-1 inhibitor 3 variant I)
158.5D4Wox405.25
158.67Klrg1Killer cell lectin-like receptor subfamily G, member 1
158.73M6prCation-dependent mannose-6-phosphate receptor precursor
158.9D4Wox495.56
159.01AicdaActivation-induced cytidine deaminase
159.03ApobecC>U-editing enzyme APOBEC-1
159.17D4Mgh105.85
159.19NanogNanog homeobox
Pia27a, RNO4, 159.3 Mb159.21Slc2a3Solute carrier family 2 (facilitated glucose transporter), member 3
159.33C3ar1Complement component 3a receptor 1
159.33D4Got1265.86
159.43APLECClec4a1
Dcir3, Dcir2, Clecsf6, AplrA1 and Dectin2p
159.89D4Kir464.69
159.90 to 159.96Clec4d, Clecsf9
160.1LOC500312Putative pheromone receptor V2R1-1 (fragment).
Pia28, RNO4, 161.0 Mb160.64C1sComplement C1s subcomponent precursor
160.52D4Got1343.5§
160.85Ptpn6Tyrosine-protein phosphatase non-receptor type 6
160.89D4Got344.02§
161CD4T cell surface glycoprotein CD4 precursor
161.03Lag3Lymphocyte activation gene 3 protein precursor (CD223 antigen)
161.21Chd4Chromodomain helicase-DNA-binding protein 4
161.7Vwfvon Willebrand factor (fragment)
162.18Tnfrsf1aTumour necrosis factor receptor superfamily member 1A precursor
162.89D4Got1313.08§
163.47Fgf23Fibroblast growth factor 23 precursor
163.5AU0287663.28§
165.51Pzpα1 Macroglobulin precursor
165.7Klrb1bKiller cell lectin-like receptor subfamily B member 1B allele A
165.99OcilOsteoclast inhibitory lectin
166.1LOC986800C-type lectin
  • The table shows the position of QTLs, with genes in bold type at each end of confidence intervals (maximum LOD−1LOD) and selected additional genes (genes and positions were retrieved from National Center for Biotechnology Information (NCBI) rat genome assembly Rat Genome Sequencing Consortium (RGSC) V.3.4 at http://www.ncbi.nlm.nih.gov).

  • *LOD for sensitivity; †LOD for severity; ‡known arthritis determinant; §LOD for chronic arthritis.

  • APLEC, a gene cluster encoding C-type lectin-like receptors; LOD, logarithm of odds; Mb, mega-base pairs.