Table 3

Position mapped arthritis quantitative trait loci (QTLs) on Rattus norvegicus chomosome (RNO)12 and RNO10, and selected genes

QTLPosition (Mb)MarkerLOD*GeneGene name
Pia 4, RNO12, 23.5 Mb22.98Rfc2Replication factor C2
23.31Gtf2ird1General transcription factor II I repeat domain-containing 1
23.36D12Got465.91
23.476.00Gtf2iGeneral transcription factor II I
23.58Ncf1Neutrophil cytosolic factor 1
23.58D12Kir75.99
23.63D12Kir135.60
24GatsSimilar to opposite strand transcription unit to STAG3
Pia 30, RNO10, 97.2 Mb96.67D10Rat152.39
96.6LOC498015Similar to phosphatidylinositol transfer protein, cytoplasmic 1 isoform b (PITPNC1)
96.89Psmd12Proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
96.95HelzHelicase with zinc finger domain (predicted)
97.11Cacng1Calcium channel, voltage-dependent, γ subunit 1
97.14Cacng4Calcium channel, voltage-dependent, γ subunit 4
97.15D10Rat133.49
97.3Cacng5Calcium channel, voltage-dependent, γ subunit 5
97.37PrkcaProtein kinase Cα
97.72ApohApolipoprotein H
98.3Axin2Axin2
98.39D10Mco152.48
Pia 31, RNO10, 105.1 Mb104.56AU0472262.33
104.56RGD1562969Similar to Tweety homologue 2 (TTYH2, predicted)
104.61Dnai2Dynein, axonemal, intermediate polypeptide 2
104.74Gprc5cG protein-coupled receptor, family C, group 5, member C
105.01LOC498022Similar to immunoglobulin superfamily, member 7
105.09RGD1560640Similar to solute carrier family 25, member 5 (predicted)
105.1Cd300leCD300 antigen-like family member E (predicted)
105.12LOC690076Similar to immune receptor expressed on myeloid cells 2
105.13D10Got1553.21
105.14D10Got1583.23
105.19Cd300lfCD300 antigen-like family member F
105.24Slc9a3r1Solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 reg. 1
105.33Grin2cGlutamate receptor, ionotropic, NMDA2C
105.44D10Got1573.11
105.48Ict1Immature colon carcinoma transcript 1 (predicted)
105.54LOC690212Similar to solute carrier family 16, member 5
105.89D10Rat72.98
105.99LOC690323Similar to myosin XVB pseudogene (MYO15B)
106.08Itgb4Integrin β4 precursor (CD104 antigen).
106.12Galk1Galactokinase
107.95Socs3Suppressor of cytokine signalling 3
108.01RGD1305052Similar to phosphatidylglycerophosphate synthase 1
  • The table shows position of QTLs, with genes in bold type at each end of confidence intervals (maximum LOD−1LOD) and selected additional genes (genes and positions were retrieved from the National Center for Biotechnology Information (NCBI) rat genome assembly Rat Genome Sequencing Consortium (RGSC) V.3.4 at http://www.ncbi.nlm.nih.gov).

  • *LOD for sensitivity; †known arthritis determinants used as reference.

  • LOD, logarithm of odds; Mb, mega-base pairs.