Table 2

Change in scores and number of patients with progression and regression exceeding the smallest detectable change

Change at 6 months*Number of patients with change at 6 months above SDC regression/none/progressionChange at 12 months*Number of patients with change at 12 months above SDC regression/none/progression
Per-protocol (n = 35)
S/vdH total scoreMean (95% CI)1.1 (−0.1 to 2.2) (NS)4/22/90.6 (−0.7 to 1.8) (NS)8/21/6
Median (range)0 (−5 to 12)0 (−4 to 15)
S/vdH erosion scoreMean (95% CI)0.5 (−0.1 to 1.2) (NS)2/26/70.4 (−0.2 to 0.9) (NS)3/25/7
Median (range)0 (−3 to 6)0 (−3 to 4)
S/vdH narrowing scoreMean (95% CI)0.5 (−0.3 to 1.3) (NS)5/21/90.2 (−0.7 to 1.1) (NS)7/23/5
Median (range)0 (−5 to 9)0 (−4 to 11)
CT erosion scoreMean (95% CI)0.6 (−0.4 to 1.6) (NS)4/25/61.1 (−1.5 to 3.7) (NS)6/23/6
Median (range)0 (−3 to 16)0 (−4 to 44)
CT erosion volume (mm3)†Mean (95% CI)5 (−11 to 21) (NS)4/26/4−4 (−22 to 14) (NS)8/21/5
Median (range)−1 (−102 to 215)−1 (−183 to 154)
Intention-to-treat (n = 52)
S/vdH total scoreMean (95% CI)0.4 (−0.4 to 1.3) (NS)9/34/90.3 (−0.6 to 1.1) (NS)11/34/7
Median (range)0 (−5 to 12)0 (−4 to 15)
S/vdH erosion scoreMean (95% CI)0.2 (−0.3 to 0.7) (NS)4/41/70.2 (−0.2 to 0.6) (NS)4/41/7
Median (range)0 (−3 to 6)0 (−3 to 4)
S/vdH narrowing scoreMean (95% CI)0.2 (−3 to 0.8) (NS)9/33/100.1 (−0.5 to 0.7) (NS)9/37/6
Median (range)0 (−5 to 9)0 (−4 to 11)
CT erosion scoreMean (95% CI)0.5 (−0.2 to 1.2) (NS)5/38/90.9 (−0.9 to 2.6) (NS)7/36/9
Median (range)0 (−3 to 16)0 (−4 to 44)
CT erosion volume (mm3)Mean (95% CI)3 (−7 to 14) (NS)4/43/5−2 (−14 to 10) (NS)9/36/7
Median (range)0 (−102 to 215)0 (−183 to 154)
  • Values on change scores are presented as mean (95% confidence interval) and median (range).

  • *Negative values indicate a decrease compared with baseline; †n = 34 (one patient not included in this analysis owing to technical problems with CT at one time point).

  • CT, computed tomography; NS, non-significant difference compared with baseline (Wilcoxon); SDC, smallest detectable change; S/vdH, Sharp/van der Heijde.