| ΔDAS28 score | p Value | ||
| Responders (n = 70) ⩾1.2 | Non-responders (n = 33) <1.2 | ||
| Cytokines (IOD/mm2): | |||
| TNFα lining | 48 214 (29 116–88 971) | 36 376 (23 394–54 271) | 0.047 |
| TNFα sublining | 77 947 (38 710–123 535) | 46 033 (19 890–78 129) | 0.008 |
| IL1β | 56 278 (31 063–81 655) | 54 484 (32 098–129 041) | 0.814 |
| IL6 | 50 537 (41 939) | 38 364 (28 527) | 0.135 |
| IL10 | 131 106 (87 359) | 115 964 (83 953) | 0.415 |
| IL18 | 9530 (12 086) | 7009 (7470) | 0.289 |
| Cellular markers (counts/mm2 ) | |||
| CD55 | 652 (418) | 694 (389) | 0.895 |
| CD3 | 149 (66–385) | 47 (22–163) | 0.001 |
| CD68 lining | 374 (253) | 295 (184) | 0.130 |
| CD68 sublining | 576 (428) | 387 (338) | 0.029 |
| CD163 | 1100 (432) | 878 (433) | 0.017 |
| CD22 | 54 (99) | 47 (111) | 0.756 |
| CD38 | 284 (384) | 325 (556) | 0.661 |
| MRP8 | 139 (35–294) | 53 (19–135) | 0.018 |
| MRP14 | 159 (34–526) | 51 (18–166) | 0.024 |
| Adhesion molecules (IOD/mm2) | |||
| ICAM | 30 790 (33 016) | 22 321 (21 706) | 0.195 |
| VCAM | 80 065 (52 630) | 70 701 (44 574) | 0.387 |
| E-Selectin | 37 651 (40 134) | 30 488 (29 972) | 0.373 |
| Growth factors (IOD/mm2 ) | |||
| VEGF | 18 252 (78 689) | 5776 (5372) | 0.374 |
| bFGF | 209 (736) | 64 (163) | 0.276 |
*Data are presented as mean (SD) or median (interquartile range), whichever appropriate. p Values<0.05 (two-sided) were considered significant.
bFGF, basic fibroblast growth factor; ICAM, intercellular adhesion molecule; IF, interferon; IOD, integrated optical density; MRP, myeloid related protein; TNF, tumour necrosis factor; VCAM, vascular cell adhesion molecule; VEGF, vascular endothelial growth factor.