Table 2 Associations of studied synovial predictors with clinical response
ΔDAS28 scorep Value
Responders (n = 70) ⩾1.2Non-responders (n = 33) <1.2
Cytokines (IOD/mm2):
TNFα lining48 214 (29 116–88 971)36 376 (23 394–54 271)0.047
TNFα sublining77 947 (38 710–123 535)46 033 (19 890–78 129)0.008
IL1β56 278 (31 063–81 655)54 484 (32 098–129 041)0.814
IL650 537 (41 939)38 364 (28 527)0.135
IL10131 106 (87 359)115 964 (83 953)0.415
IL189530 (12 086)7009 (7470)0.289
Cellular markers (counts/mm2 )
CD55652 (418)694 (389)0.895
CD3149 (66–385)47 (22–163)0.001
CD68 lining374 (253)295 (184)0.130
CD68 sublining576 (428)387 (338)0.029
CD1631100 (432)878 (433)0.017
CD2254 (99)47 (111)0.756
CD38284 (384)325 (556)0.661
MRP8139 (35–294)53 (19–135)0.018
MRP14159 (34–526)51 (18–166)0.024
Adhesion molecules (IOD/mm2)
ICAM30 790 (33 016)22 321 (21 706)0.195
VCAM80 065 (52 630)70 701 (44 574)0.387
E-Selectin37 651 (40 134)30 488 (29 972)0.373
Growth factors (IOD/mm2 )
VEGF18 252 (78 689)5776 (5372)0.374
bFGF209 (736)64 (163)0.276
  • *Data are presented as mean (SD) or median (interquartile range), whichever appropriate. p Values<0.05 (two-sided) were considered significant.

  • bFGF, basic fibroblast growth factor; ICAM, intercellular adhesion molecule; IF, interferon; IOD, integrated optical density; MRP, myeloid related protein; TNF, tumour necrosis factor; VCAM, vascular cell adhesion molecule; VEGF, vascular endothelial growth factor.