Schirmer I test, 30% or more worsening | UWS, 30% or more worsening | |||||||||
No | n | Yes | n | p Value | No | n | Yes | n | p Value | |
Age (years) | 59.0 (51.0–67.0) | 77 | 57.0 (48.8–65.3) | 34 | 0.37 | 57.0 (49.3–65.0) | 72 | 56.5 (48.0–65.0) | 42 | 0.89 |
Years since diagnosis | 5.0 (2.0–9.0) | 77 | 7.0 (3.0–9.0) | 34 | 0.54 | 5.0 (2.3–8.0) | 72 | 6.0 (3.0–9.3) | 42 | 0.41 |
Focus score | 1.0 (1.0–2.0) | 67 | 2.0 (1.0–4.0) | 27 | 0.05* | 1.0 (1.0–3.0) | 66 | 2.0 (1.0–4.0) | 41 | 0.02 |
ESR (mm/h) | 20.0 (13.0–38.0) | 35 | 19.0 (11.0–25.0) | 16 | 0.19 | 19.0 (11.0–29.0) | 39 | 18.0 (11.0–28.0) | 23 | 0.94 |
IgG (g/litre) | 13.0 (10.8–20.2) | 72 | 15.9 (11.8–20.0) | 33 | 0.16 | 13.4 (11.4–18.5) | 67 | 14.8 (11.5–21.3) | 41 | 0.27 |
IgA (g/litre) | 2.4 (1.7–3.2) | 72 | 2.6 (2.1–3.4) | 33 | 0.34 | 2.3 (1.7–3.2) | 67 | 2.4 (1.8–3.4) | 41 | 0.86 |
IgM (g/litre) | 1.3 (1.0–2.0) | 72 | 1.1 (0.9–1.8) | 33 | 0.63 | 1.2 (1.0–1.7) | 67 | 1.4 (1.1–2.2) | 41 | 0.10 |
C3 (g/litre) | 1.0 (0.8–1.3) | 35 | 1.1 (0.9–1.4) | 17 | 0.34 | 1.1 (1.0–1.3) | 33 | 1.0 (0.8–1.2) | 29 | 0.08 |
C4 (g/litre) | 0.21 (0.15–0.27) | 35 | 0.20 (0.16–0.27) | 17 | 0.76 | 0.20 (0.15–0.27) | 33 | 0.19 (0.16–0.24) | 29 | 0.80 |
Low C3 or C4† | 12 (34.3%) | 35 | 5 (29.4%) | 17 | 1.00 | 5 (15.2%) | 33 | 11 (37.9%) | 29 | 0.05 |
ANA† | 41 (56.9%) | 72 | 18 (54.5%) | 33 | 0.83 | 35 (51.5%) | 68 | 24 (58.5%) | 41 | 0.55 |
Anti-SSA antibodies† | 31 (43.1%) | 72 | 18 (54.5%) | 33 | 0.30 | 27 (39.7%) | 68 | 22 (55.0%) | 40 | 0.16 |
Anti-SSB antibodies† | 17 (23.6%) | 72 | 10 (30.3%) | 33 | 0.48 | 16 (23.5%) | 68 | 12 (29.3%) | 41 | 0.51 |
Age and years since diagnosis are indicated. Values are the median (quartiles) with p values from the Mann–Whitney U test, if not otherwise indicated.
* Exact 3-decimal p value: 0.052. † Number of patients (%) with positive test for C3 or C4; ANA; SSA; or SSB. χ2 test.
ANA, antinuclear antibodies; ESR, erythrocyte sedimentation rate; SS, Sjögren syndrome; SSA, SS A antigen; SSB, SS B antigen.