Table 3 Changes from baseline to week 48 in the Health Assessment Questionnaire (HAQ) and visual analogue scale (VAS) scores on a 0–3 scale
BaselineWeek 48Change95% CI
HAQ scores
Dressing1.15 (0.16)1.49 (0.19)0.34 (0.16)0.01 to 0.67
Arising0.77 (0.13)1.09 (0.17)0.32 (0.20)–0.08 to 0.72
Eating0.81 (0.13)0.98 (0.17)0.17 (0.16)–0.16 to 0.50
Walking1.32 (0.14)1.60 (0.18)0.28 (0.16)–0.05 to 0.60
Hygiene0.98 (0.15)1.30 (0.19)0.32 (0.18)–0.04 to 0.68
Reach1.28 (0.16)1.62 (0.18)0.34 (0.16)0.01 to 0.67
Grip1.15 (0.17)1.28 (0.18)0.13 (0.17)–0.22 to 0.48
Activity1.94 (0.14)1.98 (0.17)0.04 (0.14)–0.23 to 0.32
HAQ disability index1.17 (0.11)1.39 (0.14)0.22 (0.11)–0.01 to 0.44
VAS scores
Pain0.87 (0.11)1.06 (0.13)0.19 (0.16)–0.13 to 0.51
Gastrointestinal0.44 (0.10)0.67 (0.11)0.23 (0.11)0.0 to 0.46
Lung1.71 (0.11)1.70 (0.14)–0.02 (0.14)–0.29 to 0.26
Vascular1.11 (0.13)1.32 (0.15)0.21 (0.19)–0.18 to 0.60
Digital ulcer0.58 (0.12)0.86 (0.16)0.28 (0.16)–0.03 to 0.59
Disease1.39 (0.13)1.56 (0.14)0.17 (0.13)–0.10 to 0.44
  • Values are mean (SEM), n = 47. Five patients were discontinued because of pulmonary arterial hypertension (PAH) worsening/death and were assigned the worst value observed over the analysis set at week 48, as per protocol. A negative change corresponds to an improvement of the HAQ and VAS scores.