| Haplotype* | Study | n | Frequency | Log(HsCRP)† | Se(log(HsCRP))† |
| Other‡ | GARP | 7 | 0.01 | NA | NA |
| Control | 7 | 0 | NA | NA | |
| Haplotype 1 CACAA | GARP | 46 | 0.07 | −0.074 | 0.084 |
| Control | 97 | 0.07 | NA | NA | |
| Haplotype 2 CAGAA | GARP | 199 | 0.28 | 0.123 | 0.030 |
| Control | 389 | 0.26 | NA | NA | |
| Haplotype 3 CAGGA | GARP | 7 | 0.01 | 0.209 | 0.302 |
| Control | 10 | 0.01 | NA | NA | |
| Haplotype 4 CAGGG | GARP | 188 | 0.27 | 0.137 | 0.034 |
| Control | 423 | 0.29 | NA | NA | |
| Haplotype 5 TTGGA | GARP | 217 | 0.31 | 0.217 | 0.026 |
| Control | 482 | 0.33 | NA | NA | |
| Haplotype 7/8 AAGGA | GARP | 42 | 0.06 | 0.306 | 0.062 |
| Control | 70 | 0.05 | NA | NA | |
| Total | GARP | 706 | 1 | NA | NA |
| Control | 1478 | 1 | NA | NA |
S-HsCRP, serum high sensitive C-reactive protein; GARP, Genetics of osteoARthritis and Progression; SNP, single nucleotide polymorphism; NA, not applicable.
*Genotyping was done on a Sequenom platform with slightly modified protocols. SNPs used to resolve haplotypes with gene positions relative to AFF449713 and minor allele frequencies were rs3091244, 1440 (C>T>A, 0.315/0.057), rs1417938 1919 (A>T, 0.248), rs1800947 2667 (G>C, 0.063), rs2808630 5237 (A>G, 0.268) and rs2808628 (A>G, 0.336). The latter SNP is in close linkage disequilibrium to SNP rs1205 used in the original study by Carlson et al6 of which the haplotype nomenclature used was adapted. †Levels displayed are the expected haplotypic contribution to the mean log(S-HsCRP) level of carriers as calculated by the Thesias program. In individuals the expected S-HsCRP level is determined by the contribution of the two carried haplotypes. The Thesias program does not allow correction for familial relationship. ‡Rare haplotypes with frequencies below 0.01 were pooled as “other”.