Table 2 Effect of etanercept treatment on serum acute phase parameters as well as tumour necrosis factor α and interleukin 6 concentrations in V173D mutation-positive family members

	1-I.2	1-II.1	1-II.3
CRP (mg/l)
Before etanercept	26	121	268
Etanercept for 3 months	10	1	7
Etanercept for 6 months	108	3.1	1
Etanercept for 12 months	4	18.5	39

ESR (mm/1st h)
Before etanercept	60	72	70
Etanercept for 3 months	16	4	8
Etanercept for 6 months	1	6	10
Etanercept for 12 months	8	8	14

TNFα (pg/ml)
Before etanercept	19	15	64
Etanercept for 3 months	251	190	198
Etanercept for 6 months	111	86	96
Etanercept for 12 months	37	30	36

IL6 (pg/ml)
Before etanercept	3	3	82
Etanercept for 3 months	3	10	3
Etanercept for 6 months	7	<3	3
Etanercept for 12 months	4	<3	5

CRP, C-reactive protein (normal <5 mg/l); ESR, erythrocyte sedimentation rate (normal <10 mm/1st h); IL6, interleukin 6 (normal <3 pg/ml); TNFα, tumour necrosis factor α (normal <20 pg/ml).