Table 4 Multivariate logistic regression of independently associated variables in the low and high interferon (IFN)-regulated gene signature groups: model 2
VariableOdds ratio* (95% CI)p Value
Age (years)0.949 (0.921 to 0.977)<0.001
Immunological component of SLEDAI-2K†1.600 (1.164 to 2.217)0.004
Anti-U1 RNP antibody1.604 (1.127 to 2.318)0.009
  • As in model 1, age, disease duration and SDI were entered as continuous variables. Sex, race, prednisone, antimalarials and immunosuppressives were entered as categorical variables. In this model, additional variables included individual components of SLEDAI-2K grouped in organ systems, CRP and autoantibody profile. All variables relate to the time of the study.

  • *Odds ratio of belonging to the high IFN-regulated gene signature group. †Increased anti-dsDNA antibody and/or low complement.

  • CRP, C-reactive protein; SDI, Systemic Lupus International Collaborative Clinics/American College of Rheumatology (SLICC/ACR) Damage Index; SLE, systemic lupus erythaematosus; SLEDAI-2K, SLE Disease Activity Index 2000.