Material | n | Genotype count (%) | MAF | Allele C vs T | Genotype CC vs CT + TT | ||||
CC | CT | TT | C | OR (95% CI) | p Value | OR (95% CI) | p Value | ||
RA | 686 | 141 (21) | 346 (50) | 199 (29) | 0.46 | 1.16 (1.01 to 1.33) | 0.041 | 1.30 (1.01 to 1.67) | 0.040 |
JIA | 512 | 105 (21) | 246 (48) | 161 (31) | 0.45 | 1.10 (0.94 to 1.28) | 0.22 | 1.30 (0.99 to 1.70) | 0.062 |
SLE | 163 | 24 (15) | 93 (57) | 46 (28) | 0.43 | 1.04 (0.82 to 1.32) | 0.72 | 0.87 (0.55 to 1.38) | 0.55 |
UC | 326 | 49 (15) | 172 (53) | 105 (32) | 0.41 | 0.97 (0.81 to 1.16) | 0.72 | 0.89 (0.63 to 1.26) | 0.51 |
CD | 142 | 27 (19) | 73 (51) | 42 (30) | 0.45 | 1.11 (0.86 to 1.42) | 0.42 | 1.18 (0.75 to 1.85) | 0.47 |
PSC | 360 | 65 (18) | 176 (49) | 119 (33) | 0.43 | 1.01 (0.85 to 1.20) | 0.89 | 1.11 (0.81 to 1.52) | 0.53 |
Controls | 982 | 163 (17) | 503 (51) | 316 (32) | 0.42 | – | – | – | – |
n Refers to the number of genotyped individuals or families (genotyping success rate >95%). p Values are for Pearson χ2 test.
CD, Crohn disease; JIA, juvenile idiopathic arthritis; MAF, minor allele frequency (C allele); OR, odds ratio; PSC, primary sclerosing cholangitis; RA, rheumatoid arthritis; SLE, systemic lupus erythaematosus; UC, ulcerative colitis.