Table 1 Clinical characteristics, activity scores, and morphological signs of vasculitis
Patient/sex/age (years)Positive temp artPMRCRP (mg/l)ESR(mm/1st h)BVAS.2Thoracic activity*PET whole- body act†Immunosuppressive treatment‡Aortic wall ⩾4 mmVascular stenosesArm claudicationAortic aneurysm
PETMRI
1/F/67+45 (<5)54 (20)9 (7)45 (3)7GC, MTX (↑GC, MTX)+++
2/F/67+1004813538GC (GC, MTX)+
3/F/59+44 (22)56 (50)11 (2)2 (0)1 (0)2 (0)GC (GC, MTX)
4/F/738 (16)68 (73)11 (3)12 (2)1GC, MTX (↑GC, MTX)+
5/F/64++<5 (<5)44 (42)2 (1)3 (0)4 (4)7 (0)GC, Cyc (GC, Cyc)+++
6/F/75+<5242020GC, MTX (GC, MTX)+
7/F/75+26405202GC (↑GC)
8/M/60++12828222GC (GC, MTX)+
9/M/73++<5 (<5)22 (13)7 (1)0 (0)0 (0)1 (2)GC, MTX (GC, MTX)++
10/F/6616909013GC (↑GC)
11/F/80+1085012003GC (GC, Cyc)
12/F/70++13608113GC, MTX (GC, Cyc)
13/M/63+10 (<5)34 (20)9 (3)2 (0)5 (1)7 (0)GC, Cyc (GC, MTX, E)+++
14/F/7616 (34)31 (48)5 (5)1 (2)5 (4)2 (5)GC, Cyc (↑GC, Cyc)+
15/F/7331177020GC, MTX (GC, Cyc)++
16/M/61<5 (<5)5 (9)1 (0)01 (1)1GC (GC)
17/F/53<5201445GC, MTX (GC, MTX)+
18/F/62+<5 (<5)19 (12)1 (2)0 (0)1 (1)0GC, MTX (GC, MTX)++
19/M/69+<5 (<5)14 (13)2 (0)0 (0)2 (3)3 (2)GC, MTX (GC, Cyc)++
20/F/60<5183111GC, MTX (GC, Cyc)++
21/F/59++98616111GC, MTX (GC, MTX, E)
22/F/78+23247090GC, Cyc (↑GC, Cyc)+
23/F/62+20608010GC (GC, MTX)
24/F/57<5 (<5)24 (20)3 (0)0 (0)7 (7)3 (2)GC, MTX (↑GC, Cyc)+++
25/F/52<5 (<5)42 (15)7 (0)9 (0)712 (0)GC, Cyc (↑GC, Cyc)++
  • *Thoracic activity: range 0–12 (comprehensive score of inflammatory activity in four vascular territories of the thoracic aorta and the supra-aortic arteries as assessed by MRI and PET: 0, no inflammatory activity; 1, slight disease activity; 2, marked activity; 3, intensive activity). †PET whole body activity: range 0–18 (including the abdominal aorta and the lower extremity arteries); in parentheses—follow-up data at the time of repeated imaging. ‡Immunosuppressive treatment: in parentheses—change of treatment, ↑increased dose.

  • BVAS.2, Birmingham Vasculitis Activity Score; CRP, C-reactive protein (normal range: <5 mg/l); Cyc, cyclophosphamide; E, etanercept; ESR, erythrocyte sedimentation rate according to the Westergren method (mm at the end of the first hour); GC, glucocorticosteroids; MTX, methotrexate; PMR, polymyalgia rheumatica; positive temp art, positive biopsy of the temporal artery.