Cytokine quartiles (pg/ml)* | Patients with progression, no. | Patients without progression, no. | Adjusted RR (95% CI)† | p Value |
IL1β: | ||||
547–2045 | 7 | 14 | 1 | – |
2046–3073 | 5 | 16 | 0.8 (0.2 to 1.8) | 0.640 |
3074–4209 | 9 | 13 | 1.3 (0.5 to 2.2) | 0.495 |
4210–11 459 | 8 | 13 | 1.3 (0.5 to 2.0) | 0.604 |
TNFα: | ||||
2924–5207 | 2 | 19 | 1 | – |
5208–7087 | 7 | 14 | 4.5 (0.8 to 9.1) | 0.074 |
7088–10 045 | 10 | 12 | 5.5 (1.2 to 9.5) | 0.031 |
10 046–21 405 | 10 | 11 | 6.1 (1.4 to 9.8) | 0.024 |
IL1Ra: | ||||
12 742–19 191 | 4 | 17 | 1 | – |
19 192–23 584 | 8 | 13 | 2.1 (0.8 to 3.7) | 0.124 |
23 585–28 317 | 9 | 13 | 2.3 (0.8 to 4.0) | 0.117 |
28 318–57 311 | 8 | 13 | 2.1 (0.7 to 3.9) | 0.151 |
IL10: | ||||
182–520 | 3 | 18 | 1 | – |
521–720 | 8 | 13 | 2.7 (0.8 to 5.3) | 0.089 |
721–936 | 6 | 16 | 2.0 (0.5 to 4.7) | 0.284 |
937–2117 | 12 | 9 | 4.3 (1.7 to 6.2) | 0.006 |
*Quartiles of cytokine production, based on the distribution of IL1β, TNFα, IL1Ra) and IL10 production in the whole population. †The risk ratios (RRs) are adjusted for age, sex and body mass index. The 95% CIs are based on robust standard errors to take into account the intrafamily effect.