Table 2 Regimen used in severe systemic sclerosis (SSc) patients treated by autologous haematopoietic stem cell transplantation with at least 6 months follow-up after the procedure
Number of patients (%) total n = 26
Mobilisation procedure:
CMP 2 g/m2/d, two successive days + G-CSF10 (39%)
CMP 4 g/m2/d, one day + G-CSF16 (62%)
Number of apheresis/patient1.2 (0–2)
No mobilisation and no selection1 (4%)
No CD34+ selection1 (4%)
CD34+ selection24 (92%)
CD34+ 106/kg6.7 (2.4–17.4)
Conditioning regimen:
CMP alone (200 mg/kg ×4)25 (96%)
ALG + CMP (200 mg/kg ×4)1 (4%)
Autologous transplantation26
CD34+ PBSC24 (92%)
Non-selected PBSC1 (4%)
Bone marrow stem cells1 (4%)

  • ALG, anti-lymphocyte globulins; CMP, cyclophosphamide; PBSC, peripheral blood stem cell.